Browse our Short Reports

Page 7 of 60
    1. Microbiology and Infectious Disease

    A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

    Jessie Kulsuptrakul, Elizabeth A Turcotte ... Patrick S Mitchell
    HIV-1 infection activates the human CARD8 inflammasome via innate immune recognition of HIV-1 viral protease activity.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids

    Galina Popova, Hanna Retallack ... Tomasz Nowakowski
    Combination of primary brain culture and single-cell RNA sequencing in brain organoids identifies microglia as the main target of rubella virus infection.
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    • Compelling
    1. Developmental Biology
    2. Genetics and Genomics

    Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest

    Lingli Huang, Wenqing Li ... Jianqiang Bao
    Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31comet is required for human oocyte maturation.
    1. Microbiology and Infectious Disease

    Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

    Daan F van den Berg, Baltus A van der Steen ... Stan JJ Brouns
    A new perspective on the 50-year old mystery of why phages encode their own tRNAs.
    1. Ecology
    2. Evolutionary Biology

    Metabolic consequences of various fruit-based diets in a generalist insect species

    Laure Olazcuaga, Raymonde Baltenweck ... Julien Foucaud
    Metabolomic analyses indicate that diet generalism may stem from a neutral metabolic response to different chemistries, rather than from an accumulation of specific adaptations.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

    Kanishk Jain, Matthew R Marunde ... Brian D Strahl
    MLL1-mediated H3K4 methylation is directly enhanced by cis-tail H3 acetylation, as shown through both in vitro and in vivo experiments.
    1. Neuroscience

    Self-organization of songbird neural sequences during social isolation

    Emily L Mackevicius, Shijie Gu ... Michale S Fee
    In juvenile songbirds, neural sequences pre-exist tutor exposure, and the process of learning a new song may make use of existing neural sequences as a stable substrate for new behavioral changes.
    1. Neuroscience

    Theta- and gamma-band oscillatory uncoupling in the macaque hippocampus

    Saman Abbaspoor, Ahmed T Hussin, Kari L Hoffman
    Oscillations that co-occur in hippocampal CA1 during exploration in the rodent are shown to segregate according to exploratory and sleep states in the primate.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics of a dynamic cell behavior in murine airways

    Sheldon JJ Kwok, Daniel T Montoro ... Vladimir Vinarsky
    Live imaging of cells in an intact murine tissue combined with single-cell sequencing reveals a unique transcriptional signature of an observed cellular behavior.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the endothelin-1-ETB-Gi complex

    Fumiya K Sano, Hiroaki Akasaka ... Osamu Nureki
    The cryo-EM structure of ETB-Gi complex, obtained using the Fusion-G system, provides insights into the distinct activation mechanism and G-protein promiscuity of ETB, aiding in the design of ETB agonists for therapeutic applications.