Browse our latest Chromosomes and Gene Expression articles

A combination of single-cell analysis, genomics, and simulations shows that a glutamine-rich low-complexity sequence in the SWI/SNF chromatin remodeling complex senses transient intracellular acidification as a signal for cells to switch their global transcriptional program.

Allele-specific gene expression can affect the results and interpretation of transcriptomic analyses in zebrafish mutants and has broader implications for work in other outbred organisms.

Adenine and cytosine base editing of highly homologous HBG proximal promoter identifies novel target sites that result in adult to fetal globin switching without causing 4.9 kb large deletions.

Pioneering activity may be a property of all transcription factors with sufficient affinity for their targets rather than a property of specific classes of transcription factors.

Double-stranded precursors of siRNAs involved in RNA-directed DNA methylation have initiating sequences and overhangs imparted by the RNA polymerases that synthesize them, programming alternative dicing reactions that diversify the siRNA pool.

Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.

Mer2 interacts directly with meiotic chromatin, axial proteins, and the DNA break forming machinery to facilitate the formation of meiotic double-strand breaks.

Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.

Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.

A single origin–recognition complex (ORC) directs loading of a pair of head-to-head Mcm2-7 replicative DNA helicases by forming a protein tether to the first helicase, releasing from its initial DNA-binding site, and rebinding the origin DNA in the opposite orientation.