Browse our latest Chromosomes and Gene Expression articles

The natural compounds cordycepin and mycophenolic acid stimulate alternative polyadenylation through opposing effects on transcriptional rate.

For poly(A)-tail length to influence mRNA translational efficiency, poly(A)-binding protein (PABPC) must be limiting, mRNAs lacking PABPC must be stable, and translation initiation must be sensitive to PABPC levels.

Longer poly(A) tails improve translation in early development, but not in mature cells that have higher levels of the protein PABPC.

Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.

Micromanipulation experiments demonstrate that HP1α strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.

miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.

The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.

ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.

Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.

Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.