Christine E Cucinotta, Rachel H Dell ... Toshio Tsukiyama
Multiple mechanisms, by which a highly conserved chromatin-remodeling factor RSC facilitates initiation and maintenance of large-scale, rapid gene expression upon exit from quiescent state, have been discovered.
Modulation of histone levels in gut enterocytes by rapamycin treatment alters chromatin organisation and induces intestinal autophagy through transcriptional regulation to prevent age-related decline in the intestine and extend lifespan.
PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.
The C terminal fusion partners of TAZ-CAMTA1, YAP-TFE3 and potentially other TAZ/YAP fusion proteins in cancer recruit epigenetic modifiers that modulate a baseline TEAD-based transcriptional program.
Adrian L Sanborn, Benjamin T Yeh ... Roger D Kornberg
Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
An unbiased proteomics approach in human cells identifies ZC3H4 and shows that it is important for controlling the transcription of unstable RNA synthesized upstream of promoters and over enhancers.
Marzia Munafò, Victoria R Lawless ... Benjamin Czech
By linking export and licensing of a piRNA precursor transcript, channel nuclear pore complex subunits Nup54 and Nup58 are specifically required to silence transposons in the Drosophila ovary.
Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.
Laura Plassart, Ramtin Shayan ... Celia Plisson-Chastang
Cryo-EM and functional studies reveal how combined action of proteins RPS26/eS26 and RIO1 allows late precursors to the human small ribosomal particle to be matured into fully translation-competent 40S subunits.
