Browse our latest Genetics and Genomics articles

Page 19 of 141
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

    Mathew Thayer, Michael B Heskett ... Phillip A Yates
    Molecular genetic analyses of ASARs reveals regulation of large-scale mammalian chromosome structure and function that includes long non-coding RNAs and nuclear RNA binding proteins as essential regulators of chromosome dynamics.
    1. Cell Biology
    2. Genetics and Genomics

    Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

    Lingxiu Xu, Chengxuan Han ... Jianfeng Liu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics

    Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease

    Doo Eun Choi, Jun Wan Shin ... Jong-Min Lee
    Uninterrupted CAG repeat length determines onset age in Huntington's disease, and therefore, base editing strategies to generate CAA interruption offer new therapeutic opportunities as they diminish the disease-causing mutation.
    1. Cell Biology
    2. Genetics and Genomics

    SCC3 is an axial element essential for homologous chromosome pairing and synapsis

    Yangzi Zhao, Lijun Ren ... Zhukuan Cheng
    SCC3 not only functions as a member of cohesin complex but also participates in homologous pairing and synapsis during rice meiosis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Comparative analysis of multiplexed in situ gene expression profiling technologies

    Austin Hartman, Rahul Satija
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics

    Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species

    David V Ho, Duncan Tormey ... Peter Baumann
    Facultative parthenogenesis in whiptail lizards produces genome-wide homozygosity in offspring.
    1. Genetics and Genomics

    Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

    Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
    Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
    1. Cancer Biology
    2. Genetics and Genomics

    DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

    Jose Mario Bello Pineda, Robert K Bradley
    DUX4 expression is a common feature of metastatic tumors, where it is significantly associated with immune cell exclusion, decreased objective response to immune checkpoint blockade, and reduced patient survival.
    1. Cell Biology
    2. Genetics and Genomics

    Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

    Jiali Chen, Qinghe Zeng ... Hongting Jin
    Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
    1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.