Jonathan Zirin, Barbara Jusiak ... Norbert Perrimon
A CRISPR knock-in approach enables the efficient generation of tissue-specific LexA and QF driver lines which can simultaneously control gene expression in multiple tissues.
Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.
Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.