Browse our latest Medicine articles

Page 13 of 59
    1. Medicine

    A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

    Runze Yang, Tianhao Xu ... Weili Fu
    Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
    1. Medicine

    Resistance exercise protects mice from protein-induced fat accretion

    Michaela E Trautman, Leah N Braucher ... Dudley W Lamming
    A high-protein diet promotes unfavorable metabolic effects in mice, but resistance exercise training protects from some of these effects while promoting muscle hypertrophy and increased strength.
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Eleven strategies for making reproducible research and open science training the norm at research institutions

    Friederike E Kohrs, Susann Auer ... Tracey L Weissgerber
    Researchers and administrators can integrate reproducible research and open science practices into daily practice at their research institutions by adapting research assessment criteria and program requirements, offering training, and building communities.
    1. Medicine

    Evaluating Study Design Rigor in Preclinical Cardiovascular Research: A Replication Study

    Isaiah C. Jimenez, Gabrielle C. Montenegro ... Adrienne Mueller
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Medicine

    Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

    Dingyu Rao, Hua Lu ... Zhixian Tang
    Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
    1. Cancer Biology
    2. Medicine

    Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

    He Liu, Meisuo Liu ... Yongliang Yang
    Deep reinforcement model and experimental evaluations identified a small-molecule CRM1 inhibitor that can selectively ablate extranodal NK/T cell lymphoma cells.
    1. Medicine
    2. Cancer Biology

    Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China

    Wenhui Zhang, Yan Wang ... Zhuan Liao
    Not revised
    Reviewed Preprint v1
    1. Medicine

    GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

    Gaoran Ge, Qianping Guo ... Dechun Geng
    A new role is identified for GLI1 in modulating the inflammatory response of macrophages and the overaction of osteoclasts in collagen-induced arthritis by collaboratively regulating DNMT1 and DNMT3a.
    1. Medicine

    Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study

    Yajing Chi, Mu Su ... Huihui Li
    ctDNA predict prognosis and treatment response of mTNBC patients more sensitively than traditional tumor markers, which implies ctDNA may be valuable for individualized treatment decision-making and paves the way for a non-invasive real-time clinical management strategy in patients with mTNBC.