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Due to current levels of mobile phone ownership in Africa, it may only be possible to scale up mHealth interventions in a few countries, but not in the vast majority of the 33 countries that encompass ~60% of Africa's population.

Systematic assessment of de novo variants in patients with sporadic inborn errors of immunity led to the identification of promising candidate variants in known and novel immune genes, supporting its implementation in the routine diagnostic evaluation of these patients.

Notch signaling in human platelets functions in noncanonical juxtacrine manner to amplify platelet reactivity and thrombogenicity.

A novel species-specific detection method could obtain pathogenic bacteria information in 4 hr with high clinical sensitivity and specificity, which guided the faster antibiotic treatment in ICU and brought some clinical benefit in a real-world scenario.

The humoral and cellular immune responses were evaluated for two immunization schedules for the inactivated SARS-CoV-2 vaccine, CoronaVac, with two doses separated by 2 or 4 weeks, showing that these responses are mostly similar, with differences in neutralization capacities.

The immune system in the vagina becomes more active when young women begin to have sexual intercourse, and this immune activity could influence the risk of acquiring sexually transmitted infections.

An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.

Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.

Extrachromosomal circular DNA will hold great promise in future biomedical research and clinical translational application.

Immune markers measured at the early stage of COVID-19 infection are associated with various clinical outcomes and can be used to predict disease progression, T cell memory, viral shedding, and the antibody response of the COVID-19 patients.