Browse our Research Articles

Page 17 of 1,370
    1. Neuroscience

    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

    Erin M Ritchie, Dilan Acar ... Yishi Jin
    DLK signaling network reveals the conserved function in neuritogenesis and synapse formation, and highlights the regulation of c-Jun translation and microtubule homeostasis in hippocampal selective neuron vulnerability.
    1. Cancer Biology

    Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

    Yang Peng, Jing Yang ... Liang Weng
    Derived from scRNA-seq, SLC26A3 is a potential therapeutic target to improve the efficacy of immunotherapy, as well as a potential diagnostic indicator to reduce post-surgical upstaging, for cervical adenocarcinoma.
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey HC Yao
    Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.
    1. Neuroscience

    Aminergic and peptidergic modulation of insulin-producing cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    The combination of receptor expression analysis, optogenetics, physiological approaches, and connectomics reveals how a heterogeneous population of insulin-producing cells in Drosophila integrates diverse modulatory inputs to adjust insulin release.
    1. Developmental Biology

    The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

    Jiayin Gao, Jiawei Wang ... Keliang Wu
    HSPA2 as a critical early regulator of the first cell-fate decision in mammalian embryos.
    1. Microbiology and Infectious Disease

    Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

    Zeng-Hang Wang, Ying An ... Tao Dong
    Structural and functional analyses identify a new family of bifunctional cell-wall-targeting type VI secretion system (T6SS) effectors and a surface-charge-engineering strategy that expands T6SS activity against Gram-positive cells.
    1. Epidemiology and Global Health

    Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study

    Yuan Zhang, Dan Tang ... Xing Zhao
    Healthy lifestyle changes, particularly improvements in diet and smoking, were inversely related to comprehensive and organ-specific biological aging in Southwest China, highlighting key intervention targets to limit aging.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

    Liyi Wang, Shiqi Liu ... Tizhong Shan
    The cytological mechanism of conjugated linoleic acids regulates fat infiltration in skeletal muscles based on pig models via using single-nucleus transcriptomics.
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Recurrent spiking networks that process input stimuli with optimal efficiency have key emerging properties that are similar to those of biological neural networks.
    1. Cell Biology
    2. Medicine

    PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

    Pengbo Chen, Bo Li ... Xinfeng Zheng
    The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal cells was characterized in vitro.