Reduced parenteral glucose during neonatal infection redirects hepatic metabolism to oxidative phosphorylation and gluconeogenesis, dampens systemic proinflammatory responses, and significantly enhances survival in preterm newborns.
Ana Catarina Costa, Blanca R Murillo ... Monica M Sousa
Proteomic analyses reveal a distinct protein signature underlying microtubule organization and regenerative asymmetries in sensory neuron axons, supported by an in vitro system replicating key features of sensory neuron biology.
Cell biological approaches and spatiotemporally resolved proteome profiling demonstrate that the chemokine receptor CCR7 can activate G proteins after being internalized into endosomes, from where it regulates Rac1-dependent chemotaxis.
Maren Klingelhöfer-Jens, Katharina Hutterer ... Tina B Lonsdorf
Childhood adversity is associated with aberrant threat learning patterns in a large healthy adult sample as evidenced by empirically testing several theories linking childhood adversity to psychopathology.
Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
A liver-specific depletion of the survival motor neuron protein in a mouse model unveils a compelling and intricate connection between liver function and pancreatic abnormalities in spinal muscular atrophy.
Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.
Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formation.
William T Redman, Santiago Acosta-Mendoza ... Michael J Goard
Grid cells within an individual module show significantly more variability in grid properties than would be expected by chance, resulting in improved neural representation of animal location in the environment.
