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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

    Liyi Wang, Shiqi Liu ... Tizhong Shan
    The cytological mechanism of conjugated linoleic acids regulates fat infiltration in skeletal muscles based on pig models via using single-nucleus transcriptomics.
    1. Neuroscience

    Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

    Sergio Casas-Tinto, Nuria Garcia-Guillen, María Losada-Perez
    Genetic and lineage-tracing analyses reveal that neuropil-associated glia can directly transdifferentiate into neurons in the adultcentral nervous system (CNS) after injury, uncovering a previously unrecognised mechanism for CNS regeneration.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Cell Biology
    2. Medicine

    PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

    Pengbo Chen, Bo Li ... Xinfeng Zheng
    The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal cells was characterized in vitro.
    1. Epidemiology and Global Health

    Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study

    Yuan Zhang, Dan Tang ... Xing Zhao
    Healthy lifestyle changes, particularly improvements in diet and smoking, were inversely related to comprehensive and organ-specific biological aging in Southwest China, highlighting key intervention targets to limit aging.
    1. Developmental Biology
    2. Neuroscience

    UNC-6/Netrin promotes both adhesion and directed growth within a single axon

    Ev L Nichols, Joo Lee, Kang Shen
    UNC-6/Netrin functions both as a short-range adhesive cue and a gradient to guide axons in vivo.
    1. Neuroscience

    Multi-dimensional social relationships shape social attention in monkeys

    Sainan Liu, Jiepin Huang ... Yan Yang
    Multi-dimensional social relationships dynamically shape attentional biases toward in-group and out-group conspecifics in monkeys, with oxytocin modulating these interactions to reveal neurobiological links between social networks and visual information processing.
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Recurrent spiking networks that process input stimuli with optimal efficiency have key emerging properties that are similar to those of biological neural networks.
    1. Neuroscience

    ThermoMaze behavioral paradigm for assessing immobility-related brain events in rodents

    Mihály Vöröslakos, Yunchang Zhang ... György Buzsáki
    The ThermoMaze behavioral paradigm enables the collection of extensive physiological data while animals remain at distinct experimenter-controlled locations during rest.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalova, Nikola Kaislerova ... Tomas Dolezal
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine

    Loss of CTRP10 results in female obesity with preserved metabolic health

    Fangluo Chen, Dylan C Sarver ... G William Wong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing