Browse our latest Chromosomes and Gene Expression articles

The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.

A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.

Chromatin modifiers shape nuclear morphology.

In songbirds, deafening leads to changes in gene expression which have now been mapped at the single-cell level across the neural circuit involved in song production.

Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.

STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.

An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.

MLL1-mediated H3K4 methylation is directly enhanced by cis-tail H3 acetylation, as shown through both in vitro and in vivo experiments.

Mice carrying a near-complete human chromosome 21 are hypermetabolic and have increased thermogenesis due to sarcolipin overexpression in the skeletal muscle, leading to persistent uncoupling of the sarco(endo)plasmic reticulum Ca²⁺ ATPase pump activity and heat generation.

Dual function of promyelocytic leukemia nuclear bodies (PML NBs) acting as buffering centers modulating the nuclear distribution of HIRA, and as chromosomal hubs regulating interferon-stimulated genes (ISGs) transcription, and thus HIRA-mediated H3.3 deposition/recycling at ISGs upon inflammatory response.