Browse our latest Genetics and Genomics articles

Page 16 of 139
    1. Developmental Biology
    2. Genetics and Genomics

    The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo

    Mengyang Shi, Jie Li ... Bin Zhou
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease

    Doo Eun Choi, Jun Wan Shin ... Jong-Min Lee
    Uninterrupted CAG repeat length determines onset age in Huntington's disease, and therefore, base editing strategies to generate CAA interruption offer new therapeutic opportunities as they diminish the disease-causing mutation.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Risk factors affecting polygenic score performance across diverse cohorts

    Daniel Hui, Scott Dudek ... Marylyn D. Ritchie
    Revised
    Reviewed Preprint v2
    Updated
    1. Cell Biology
    2. Genetics and Genomics

    SCC3 is an axial element essential for homologous chromosome pairing and synapsis

    Yangzi Zhao, Lijun Ren ... Zhukuan Cheng
    SCC3 not only functions as a member of cohesin complex but also participates in homologous pairing and synapsis during rice meiosis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Comparative analysis of multiplexed in situ gene expression profiling technologies

    Austin Hartman, Rahul Satija
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species

    David V Ho, Duncan Tormey ... Peter Baumann
    Facultative parthenogenesis in whiptail lizards produces genome-wide homozygosity in offspring.
    1. Genetics and Genomics

    Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

    Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
    Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Co-expression of the AsCas12a ultra variant, a T7 RNA Polymerase and a cytosine base editor greatly increases transfection and editing rates in Leishmania species

    Nicole Herrmann May, Annika Schmid ... Tom Beneke
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Genetics and Genomics

    DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

    Jose Mario Bello Pineda, Robert K Bradley
    DUX4 expression is a common feature of metastatic tumors, where it is significantly associated with immune cell exclusion, decreased objective response to immune checkpoint blockade, and reduced patient survival.
    1. Cell Biology
    2. Genetics and Genomics

    Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

    Jiali Chen, Qinghe Zeng ... Hongting Jin
    Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
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