The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.
Genetic association analyses in Latin American individuals revealed two additional loci associated with COVID-19 that were not previously found in other population groups.
The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.
Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
