Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

    Toyoshi Yanagihara, Kentaro Hata ... Isamu Okamoto
    Increased CD16+ T cell populations in bronchoalveolar lavage fluid highlight a potential biomarker and immune response mechanism in Pneumocystis jirovecii pneumonia.
    1. Developmental Biology
    2. Immunology and Inflammation

    Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

    Amir Hossein Kayvanjoo, Iva Splichalova ... Elvira Mass
    Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.
    1. Cell Biology
    2. Immunology and Inflammation

    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

    Cristina Cacho-Navas, Carmen López-Pujante ... Jaime Millán
    ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.
    1. Immunology and Inflammation

    Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    Tatyana O Nakonechnaya, Bruno Moltedo ... Dmitriy M Chudakov
    Digitalized TCR repertoire-based view on antigenic specificity, plasticity, and tissue residence of regulatory T cells.
    1. Immunology and Inflammation

    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

    Preksha Gaur, Yesheswini Rajendran ... Chittur Srikanth
    Rab7-mediated changes in goblet cell function play a crucial role in triggering gut inflammation during colitis.
    1. Immunology and Inflammation

    Bacterial Growth: The SagA of E. faecium

    Rishika Prasad, Robert R Jenq
    An enzyme that remodels the cell wall of Enterococcus faecium helps these gut bacteria to divide and generate peptide fragments that enhance the immune response against cancer.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

    Ayse Kilic, Arda Halu ... Scott T Weiss
    Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Immune Response: Investigating the role of vitamin D in asthma

    Siddhant Sharma, Mayank Garg
    Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

    Yuting Zhang, Min Zhang ... Guojiang Chen
    A novel antibody recognizing receptor-binding region of MARV glycoprotein was developed and displays broad-spectrum neutralizing activity to filovirus species when NPC2 was fused to the N-terminus of the mAb.