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The combination of single-cell analysis and cell fate mapping studies evidenced the presence of AIRE-expressing transit-amplifying thymic epithelial cells, which differentiate into mature medullary thymic epithelial cells expressing tissue-specific antigens.

A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.

Hematopoietic progenitor cells employ CD47 to engage thymic portal endothelial signal regulatory protein alpha for their transendothelial migration and thymic homing.

Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.

Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.

Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.

Homeostatic innate lymphoid cell abundance, adjusted for age and sex, correlates inversely with COVID-19 severity in adults and children.

Cluster analysis reveals convergent T cell clones reacting to tumor antigens, enabling intelligent optimization of cancer immunotherapy.

The interplay of the host metabolic reprogramming, its negative association with antiviral biological signaling pathways and the IFN-mediated host antiviral mechanism during Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) infection could provide attractive options for therapeutic intervention of CCHF.

Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.