Browse our latest Medicine articles

Page 34 of 59
    1. Cell Biology
    2. Medicine

    Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

    Kathryn P Trogden, Justin Lee ... Irina Kaverina
    Analysis of insulin secretion patterns in pancreatic islets shows that microtubules control β-cell heterogeneity by regulating initiation and timing of secretion hot spot activity in parallel with Ca2+ signaling.
    1. Cell Biology
    2. Medicine

    An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

    Richard K Nakamura, Lee S Mann ... Bruce Reed
    Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qualified support for double-blinded models of peer review.
    1. Cell Biology
    2. Medicine

    Funding: Blinding peer review

    Michael A Taffe
    Concealing the identity of the principal investigator only partially closes the success gap between white and African American or Black researchers in NIH grant applications.
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    Insight
    1. Medicine
    2. Neuroscience

    Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

    Angela Kim, Joseph C Madara ... Bradford B Lowell
    Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.
    1. Medicine
    2. Neuroscience

    Vasopressin: Predicting changes in osmolality

    Zhe Yang, Tongtong Wang, Yuki Oka
    Two neural circuits control the release of vasopressin in response to eating and drinking before there are any detectable changes in blood water levels.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Medicine

    The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis

    Chunbo Zhang, Tianyu Zhong ... Jianing Zhong
    A series of experiments at the molecular level reveal the underlying mechanism of how a gene activates liver glucose production to regulate the blood glucose metabolism in mice.
    1. Cell Biology
    2. Medicine

    Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome

    Saumil Sethna, Wadih M Zein ... Zubair M Ahmed
    A preclinical study using exogenous retinoids in a novel Usher syndrome 1F mouse model reveals a possible therapy to treat mutant PCDH15-mediated visual dysfunction.
    1. Medicine
    2. Neuroscience

    Reporting and misreporting of sex differences in the biological sciences

    Yesenia Garcia-Sifuentes, Donna L Maney
    A review of studies in the life sciences shows that inappropriate statistical approaches may distort conclusions on sex differences.
    1. Medicine
    2. Neuroscience

    Statistics: Sex difference analyses under scrutiny

    Colby J Vorland
    A survey reveals that many researchers do not use appropriate statistical analyses to evaluate sex differences in biomedical research.
    Version of Record
    Insight
    1. Developmental Biology
    2. Medicine

    β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

    Shikai Hu, Jacquelyn O Russell ... Satdarshan P Monga
    Ductular reaction often observed in chronic liver pathologies such as in cystic fibrosis could be due to disruption of a novel complex of β-catenin-NF-κB and CFTR in cholangiocytes, which leads to persistent nuclear translocation of p65 and NF-κB activation.