Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown
MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.
Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
Giulia Leanza, Francesca Cannata ... Nicola Napoli
In individuals with type 2 diabetes, downregulation of bone canonical Wnt signaling is linked to higher levels of advanced glycation end-products within the bone, contributing to lower bone strength.
A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors involved in osteoclast–osteoblast communication and their potential as treatments for bone diseases.
