Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth Anne Schmitz
The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.
Paul Richard J Yulo, Nicolas Desprat ... Heather L Hendrickson
Fitness defects arising from deletion of the gene encoding the bacterial equivalent of actin (mreB) are readily compensated by mutations affecting cell wall synthesis.
Kathleen T Quach, Gillian A Hughes, Sreekanth H Chalasani
As Caenorhabditis elegans shifts from reactive to increasingly proactive defensive strategies, nuanced changes in interaction between SEB-3 receptor and NLP-49 peptides regulate the transitions between defensive behaviors.
Ainhoa Arbués, Sarah Schmidiger ... Damien Portevin
Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.
Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.
A novel mutant, R25CPTH, derived from a hypoparathyroidism patient, can form a dimer that activates PTH1R and enhances bone formation in female mice similar to PTH despite altered molecular properties.
Maryam Rahmati Ishka, Hayley Sussman ... Magdalena M Julkowska
Salt stress disrupts root-shoot growth coordination through SR3G, a negative regulator of salt tolerance, that affects shoot growth, root suberization, and sodium accumulation, revealing new targets for environmental resilience.
Cortex-wide projections onto primary sensory and motor areas display substantial interhemispheric symmetry in their areal input identity and are primarily feedback in nature due to dominant inputs from Layer 6.
