Browse our Research Articles

Page 11 of 1,370
    1. Neuroscience

    A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

    Lotfi Ferhat, Rabia Soussi ... Michel Khrestchatisky
    Pharmacologically induced hypothermia elicits anticonvulsant, neuroprotective, and anti-inflammatory properties.
    1. Neuroscience

    The value of initiating a pursuit in temporal decision-making

    Elissa Sutlief, Charlie Walters ... Marshall G Hussain Shuler
    Equations generalizing reward rate maximization are derived, explaining ostensible suboptimal behaviors, revealing time’s cost to comprise apportionment and opportunity costs, and identifying the misestimation in time apportionment as the actual error committed in temporal decision making by animals and humans.
    1. Immunology and Inflammation
    2. Medicine

    Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang
    Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2+Ccl7+Ccl8+C1qa+C1qb+C1qc+ pro-inflammatory macrophages, which can induce the CD8+ and Th17 memory T cells generation while inhibiting the gMDSCs production.
    1. Structural Biology and Molecular Biophysics

    Functionally important residues from graph analysis of coevolved dynamic couplings

    Manming Xu, Sarath Chandra Dantu ... Shozeb Haider
    DyNoPy is able to deconvolute communities from complicated coevolution analysis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O'Rourke ... Sunny Shin
    Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
    1. Cell Biology

    CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability

    Kaima Tsukada, Rikiya Imamura ... Mikio Shimada
    It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.
    1. Neuroscience

    Auditory cortex anatomy reflects multilingual phonological experience

    Olga Kepinska, Josue Dalboni da Rocha ... Narly Golestani
    Multilingual experience, particularly with larger phonological inventories across multilinguals’ languages, is linked to structural differences in transverse temporal gyri, highlighting experience-driven plasticity as a key factor shaping auditory cortex anatomy.
    1. Neuroscience

    Network segregation is associated with processing speed in the cognitively healthy oldest-ol

    Sara A Nolin, Mary E Faulkner ... Kristina Visscher