Browse our Research Articles

3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca²⁺ oscillations.

Phase diagrams for 140 variants of prion-like low-complexity domains are computed to establish scaling laws that quantify the impact of amino acid mutations on the thermodynamic stability of condensates.

The light-modulated protein kinase CDK5 is important for phase shifts of the circadian clock, impacting phase delays through calcium influx and signaling pathways, crucial for adapting to jet lag.

NPRL2 gene therapy induces robust antitumor immunity and overcome anti-PD1 resistance through augmenting antigen-presentation and cytotoxic T cells activation in KRAS/STK11 mutant NSCLC in humanized mouse model.

The novel live-attenuated SARS-CoV-2 nasal vaccine candidate is highly safe, induces robust cellular and mucosal immunity, and generates long-lasting neutralizing antibody titers.

Further evidence in support of a new amyloid-independent hypothesis for the pathogenesis of Alzheimer's disease is provided, with an expanded set of Alzheimer-causing mutations in the protease that produces amyloid.

A ligand independent mechanical sensitive mTORC2-PKC pathway activates Notch in the endocardium of the valve forming area.

Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.

Membrane lipids are involved in the maturation and cytotoxicity of Parkinson's synphilin-1 inclusion bodies.

Inferior parietal and lateral occipitotemporal cortex encode the effects of actions at an abstract level of representation, independently of the body movements that induce them.