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As well as preventing bone loss, bisphosphonate drugs may boost early immune responses in the lung by acting directly on alveolar macrophages that form one of the first lines of defence against infection.

Intrathecal injection of CSF1 induces greater upregulation of spinal microglial genes in male versus female mice, however, Treg depletion enhances microglial activation and restores pain hypersensitivity in the female mice.

Transmembrane protein Erd1 and the cytosolic receptor Vps74 cooperate to mediate early Golgi glycosyltransferase recycling in budding yeast.

A preclinical study using exogenous retinoids in a novel Usher syndrome 1F mouse model reveals a possible therapy to treat mutant PCDH15-mediated visual dysfunction.

6-Phosphogluconate dehydrogenase controls regulatory T cells metabolism with shifts to Th1, Th2, and Th17 phenotypes.

A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.

Inducible fate-mapping analysis demonstrates that neither microglia, CD11c⁺ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.

The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.

A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.

SUMOylation contributes to the fine-tuning of the proteostatic equilibrium of essential chloroplast protein import receptor TOC159 at early plant development.