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    1. Neuroscience

    Pain-Related Memory Impairment: How does chronic pain lead to memory loss?

    Suelen Pereira, Ivan Tomsic ... Mychael V Lourenco
    A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.
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    1. Neuroscience

    Opioids: Finding new ways to treat overdoses

    Jill R Turner, Jocelyn Martin
    Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.
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    1. Genetics and Genomics

    Down Syndrome: How a gene fuels ear infections

    Sedigheh Delmaghani, Aziz El-Amraoui
    The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.
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    1. Chromosomes and Gene Expression

    Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules

    Carlos Moreno-Yruela, Beat Fierz
    Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
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    1. Cell Biology

    Aging: Restoring bone healing potential

    Inês Sequeira
    A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
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    1. Developmental Biology

    Brain Development: Single cells tell it all

    Margaret Hines, Elias Oxman ... Irene Zohn
    A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice.
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  1. An isopod, well-adapted to the harsh conditions of arid-lands, crawls on the desert floor in search of leaf litter

    Episode 96: December 2024

    In this episode, we hear about predicting the evolution of influenza viruses, how deserts decompose matter, what worms are revealing about a gene linked to autism, and how mice detect the smell of cats.
    1. Computational and Systems Biology

    Cellular Respiration: Mapping mitochondrial aging

    Alessandro Bitto
    Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
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    1. Ecology

    Disease Transmission: Interactions between wild pigs and the spread of disease

    Mercury Shitindo
    Tracking wild pigs with GPS devices reveals how their social interactions could influence the spread of disease, offering new strategies for protecting agriculture, wildlife, and human health.
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    1. Cell Biology

    Cytoskeleton: Rearranging to resist cell death

    Dominik Brokatzky, Serge Mostowy
    Cytoskeleton rearrangements promote formation of a giant structure called a GUVac that stops cells from dying when they become detached from the extracellular matrix.
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