Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

    Roger Huerlimann, Natacha Roux ... Timothy Ravasi
    Transcriptomic analyses of Malabar grouper show pathways known to be involved in metamorphosis are also upregulated at an early stage of larval development, suggesting an additional function during early development.
    1. Chromosomes and Gene Expression

    Stem-loop and circle-loop TADs generated by directional pairing of boundary elements have distinct physical and regulatory properties

    Wenfan Ke, Miki Fujioka ... James B Jaynes
    Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.
    1. Chromosomes and Gene Expression

    Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

    Xinyang Bing, Wenfan Ke ... James B Jaynes
    Boundary:boundary pairing interactions drive TAD formation in Drosophila.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

    Ashley L Cook, Surojit Sur ... Nicolas Wyhs
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    Peng Xie, Xu Jiang ... Chengqi Lin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Real-time transcriptomic profiling in distinct experimental conditions

    Tamer Butto, Stefan Pastore ... Susanne Gerber
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DDX6 regulates translation and decay of inefficiently translated mRNAs

    Ramona Weber, Chung-Te Chang
    DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway.
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