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The atomic resolution cryo-EM structure of somatostatin receptor 2 (SSTR2) provides insights into the mechanism by which SSTRs recognize their ligands and will serve as a platform to develop selective agonists and therapeutics.

Alternative conformations of membrane protein structures can be predicted to high accuracy with AlphaFold2 by reducing the depth of the multiple sequence alignments used for modeling.

Drug targeting Nsp1-ribosome interaction shows rescue of Nsp1-mediated translation inhibition and has antiviral activity against SARS-CoV-2.

Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.

Dropouts in single cell RNA sequencing data are associated with cell states and can affect gene signature scoring if methods do not account for them.

Body mass index and adipose distribution have opposing and broad effects on human blood trait variation by Mendelian randomization analysis, helping to clarify the complex interplay between cardiometabolic traits and hematopoiesis at the genetic level.

A method to carefully measure the molecular distance between a site of interest and a reference surface by the repeated acquisition of the two image channels followed by the statistical calculation of the relative difference.

The third causative gene ZNF862 was novelly identified for hereditary gingival fibromatosis in a large Chinese family.

The phytocannabinoid cannabidiol, an antiepileptic agent whose molecular targets are unclear, was found to potently enhance current carried by cloned human Kv7.2/7.3 channels and native M-current in mouse and rat neurons.

Temperature variation caused by heatwaves and diurnal fluctuations has distinct effects on host and pathogen traits at different mean temperatures, leading to large and unexpected differences in disease burden making the impact of global warming on diseases hard to predict.