Highlights

  • Special Issue: Reproductive Health

    There is a clear need for a better understanding of the fundamental biology of reproduction and for new treatments for a range of reproductive disorders.

    Collection
  • New mechanism for mass escape

    The release of small extracellular vesicles from a larger membrane-enclosed structure can be described by a ‘torn bag’ mechanism.

    Tamás Visnovitz, Dorina Lenzinger ... Edit I Buzas
    Short Report
  • P63+ stem cells go on trial

    The results of a phase 1 clinical trial in which P63+ stem cells were given to patients with idiopathic pulmonary fibrosis are reported.

    Shiyu Zhang, Min Zhou ... Wei Zuo
    Reviewed Preprint Updated

Latest research

    1. Microbiology and Infectious Disease

    SATAY-based chemogenomic screening uncovers antifungal resistance mechanisms and key determinants of ATI-2307 and chitosan sensitivity

    Matthew T Karadzas, Agnès H Michel ... Benoît Kornmann
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Pupil dilation offers a time-window on prediction error

    Olympia Colizoli, Tessa van Leeuwen ... Harold Bekkering
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Proactive distractor suppression in early visual cortex

    David Richter, Dirk van Moorselaar, Jan Theeuwes
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

    Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    A neural network model that generates salt concentration memory-dependent chemotaxis in Caenorhabditis elegans

    Masakatsu Hironaka, Tomonari Sumi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

    Alexander J Knights, Easton C Farrell ... Tristan Maerz
    Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.
    1. Neuroscience

    Cortico-striatal action control inherent of opponent cognitive-motivational styles

    Cassandra Avila, Martin Sarter
    Electrochemical recordings of cortico-striatal glutamatergic signaling, and chemogenetic inhibition of such signaling, revealed an essential role of cortico-striatal input for cued action selection, but not for cued stopping.
    1. Computational and Systems Biology

    AI-enabled alkaline-resistant evolution of protein to apply in mass production

    Liqi Kang, Banghao Wu ... Liang Hong
    The Pro-PRIME model demonstrates the ability to engineer VHH antibody with unprecedented alkali resistance and enhanced affinity, enabling industrial applications under extreme conditions previously unattainable with natural proteins.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.