May 2024

Cover articles

    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A missing link in glycolysis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    1. Computational and Systems Biology
    2. Ecology

    Rethinking group hunting

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    1. Cancer Biology
    2. Cell Biology

    A potential drug target for pancreatic cancer

    Savvas Nikolaou, Amelie Juin ... Laura M Machesky

Highlights controls:

Research articles

    1. Medicine
    2. Microbiology and Infectious Disease

    Neuroinfectiology of an atypical anthrax-causing pathogen in wild chimpanzees

    Tobias Gräßle, Carsten Jäger ... Markus Morawski
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Unlocking the secrets of kangaroo locomotor energetics: Postural adaptations underpin increased tendon stress in hopping kangaroos

    Lauren H. Thornton, Taylor J.M. Dick ... Christofer J. Clemente
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Genetically defined nucleus incertus neurons differ in connectivity and function

    Emma D Spikol, Ji Cheng ... Marnie E Halpern
    Transgenic zebrafish generated by targeted genomic integration distinguish neuronal subtypes in the nucleus incertus that differ in their connections and functional properties.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Bacterial vampirism mediated through taxis to serum

    Siena J Glenn, Zealon Gentry-Lear ... Arden Baylink
    Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.
    1. Microbiology and Infectious Disease

    Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

    Xufeng Xie, Xi Chen ... Yongguo Cao
    Gut dysbiosis is involved in severe leptospirosis that is related to translocated microbiota-derived lipopolysaccharide.
    1. Developmental Biology

    SMAD4 promotes somatic-germline contact during murine oocyte growth

    Sofia Granados-Aparici, Qin Yang, Hugh J Clarke
    Depletion of the TGFβ signal-transducer, SMAD4, in granulosa cells of growing follicles reduces the number of filopodia, termed transzonal projections, that stably attach to and mediate communication with the oocyte.
    1. Cell Biology
    2. Genetics and Genomics

    Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

    Jiali Chen, Qinghe Zeng ... Hongting Jin
    Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
    1. Neuroscience

    Visual working memories are abstractions of percepts

    Ziyi Duan, Clayton E Curtis
    Working memory representations are not hard copies of sensory information, even in early visual cortex, but can be recoded into more abstract and goal-directed formats aligned to behavioral goals.
    1. Neuroscience

    High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

    Li A. Zhang, Peichao Li, Edward M. Callaway
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Whole-brain neural substrates of behavioral variability in the larval zebrafish

    Jason Manley, Alipasha Vaziri
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Convolutional networks can model the functional modulation of MEG responses during reading

    Marijn van Vliet, Oona Rinkinen ... Riitta Salmelin
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson’s disease

    Desirée Böck, Maria Wilhelm ... Gerald Schwank
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C Sarver, Muzna Saqib ... G William Wong
    Revised
    Reviewed Preprint v3
    1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
    1. Computational and Systems Biology
    2. Neuroscience

    Theoretical principles explain the structure of the insect head direction circuit

    Pau Vilimelis Aceituno, Dominic Dall'Osto, Ioannis Pisokas
    Three theoretical principles explain the neural activity observed in the head direction circuit of insects, the connectivity pattern underlying the circuit, and how the ubiquitous eight-column circuit structure emerged from evolutionary processes.
    1. Neuroscience

    Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem

    He-Hai Jiang, Ruoxuan Xu ... Fujun Luo
    Neurexins are essential for shaping the functional properties of glycinergic synapse in the auditory brainstem, further attesting their universal role as critical presynaptic organizers in all major fast chemical synapses.
    1. Plant Biology

    H1 restricts euchromatin-associated methylation pathways from heterochromatic encroachment

    C Jake Harris, Zhenhui Zhong ... Steven E Jacobsen
    The efficient deployment of RdDM for transposon silencing is hierarchically controlled by the linker histone H1.
    1. Ecology

    The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sucrose

    Shuai-Shuai Zhang, Pei-Chao Wang ... Chen-Zhu Wang
    The sweet taste receptors in the cotton bollworm (Helicoverpa armigera) are evolved to adapt towards the larval and adult foods with different types and amounts of sugar.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu
    SARS-CoV-2 infection reduces the intracellular levels of a human tRNA modification enzyme and alters host tRNA modification profiles.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

    Fengzhu Xiong, Andrea R. Tentner ... Sean G. Megason
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    Parveen Goyal, KanagaVijayan Dhanabalan ... Subramanian Ramaswamy
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regions

    Apiwat Sangphukieo, Pitiporn Noisagul ... Parunya Chaiyawat
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Artificial selection for microbial collective composition can succeed or fail depending on the initial and target values

    Juhee Lee, Wenying Shou, Hye Jin Park
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

    Till M. Muenker, Bart E. Vos, Timo Betz
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

    Rasa Giniūnaitė, Rahul Sharma ... Daiva Petkevičiūtė-Gerlach
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

    Yalan Jiang, Pingping He ... Xiaoou Shan
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Reactivation strength during cued recall is modulated by graph distance within cognitive maps

    Simon Kern, Juliane Nagel ... Gordon B Feld
    Items retrieved from cognitive maps are reactivated simultaneously or sequentially depending on the performance, where in the first case the reactivation strength reflects the distance within the map.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Neuroscience

    Brain representations of motion and position in the double-drift illusion

    Noah J Steinberg, Zvi N Roth ... Elisha Merriam
    The 'double-drift' illusion involves integration of retinal and non-retinal signals in the human visual cortex, providing evidence for a perceptual representation that incorporates extraretinal information.
    1. Cancer Biology
    2. Cell Biology

    mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

    Helmut Bischof, Selina Maier ... Robert Lukowski
    A novel role of the mitochondrial BKCa channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O2-independence, which is also of potential clinical relevance.
    1. Biochemistry and Chemical Biology

    Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C

    Alexander S Baier, Nathan Gioacchini ... Craig L Peterson
    Nucleosome recognition by the SWR1C chromatin remodeling enzyme requires both nucleosomal acidic patches.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
    1. Immunology and Inflammation

    Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

    Miki Kume, Hanako Koguchi-Yoshioka ... Rei Watanabe
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning

    Ruihan Dong, Rongrong Liu ... Cheng Zhu
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+- independent protein lysine deacetylase

    Yuqian Wang, Guibin Wang ... Xiangmin Lin
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

    Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth A. Schmitz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

    Yiting Li, Wenqu Yin ... Baoming Li
    Revised
    Reviewed Preprint v2
    1. Computational and Systems Biology

    Analysis of science journalism reveals gender and regional disparities in coverage

    Natalie R Davidson, Casey S Greene
    Those quoted and mentioned in stories in Nature News mostly have names associated with men and are much less likely to have names associated with East Asia.
    1. Microbiology and Infectious Disease

    The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

    João Paulo Portela Catani, Anouk Smet ... Thorsten U Vogel
    N2 neuraminidases from human H3N2 viruses from 2009 until 2017 can be subdivided into four antigenic groups, with amino acid substitutions near the catalytic site more likely impacting neuraminidase inhibition.
    1. Cancer Biology
    2. Immunology and Inflammation

    Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

    Brandon H Hayes, Mai Wang ... Dennis E Discher
    Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

    Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse
    ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.
    1. Developmental Biology

    An important role for triglyceride in regulating spermatogenesis

    Charlotte F Chao, Yanina-Yasmin Pesch ... Elizabeth Rideout
    Triglyceride plays an important role in regulating sperm development.
    1. Medicine

    Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

    Wei Chen, Yun Lu ... Yi-Ping Li
    Low expression of Cbfb may be the cause of osteoarthritis, and local admission of Cbfb may rescue and protect against osteoarthritis through decreasing Wnt/β-catenin signaling, and increasing Hippo/Yap signaling and Tgfβ/Smad2/3 signaling in osteoarthritis articular cartilage.
    1. Cell Biology
    2. Genetics and Genomics

    Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity

    Jisun So, Olivia Strobel ... Hyun Cheol Roh
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum: A containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

    S. P. Maher, M. A. Bakowski ... D. E. Kyle
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Distinct neural bases of subcomponents of the attentional blink

    Swagata Halder, Deepak Velgapuni Raya, Devarajan Sridharan
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Amoeboid cells undergo durotaxis with soft end polarized NMIIA

    Chenlu Kang, Pengcheng Chen ... Congying Wu
    Revised
    Reviewed Preprint v3
    1. Developmental Biology

    Flamingo participates in multiple models of cell competition

    Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D Axelrod
    Revised
    Reviewed Preprint v3
    1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden
    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

    Bing Liang Alvin Chew, AN Qi Ngoh ... Dahai Luo
    Molecular architecture of the secreted NS1 dimer from dengue virus infection in complex with a high density lipoprotein particle.
    1. Genetics and Genomics
    2. Neuroscience

    Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes

    Donghui Yan, Bowen Hu ... Qiongshi Lu
    BADGERS, as a new powerful method for conducting polygenic score-based biobank-wide association scans, identified 48 significant associations for AD and 41 significant associations for a variety of AD endophenotypes.
    1. Microbiology and Infectious Disease

    A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

    Swagata Bose, Satya Ranjan Sahu ... Narottam Acharya
    A detailed characterizations of EDTA-treated Candida albicans cells both in vitro and pre-clinical models led to discovery of a potential live whole-cell vaccine against fungal infections.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Spotless, a reproducible pipeline for benchmarking cell type deconvolution in spatial transcriptomics

    Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys
    Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M Jore
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    A Connectome of the Male Drosophila Ventral Nerve Cord

    Shin-ya Takemura, Kenneth J Hayworth ... Stuart Berg
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

    Jewoo Seo, Seung Ha Kim ... Sang Jeong Kim
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Value construction through sequential sampling explains serial dependencies in decision making

    Ariel Zylberberg, Akram Bakkour ... Michael N Shadlen
    Revised
    Reviewed Preprint v2
    1. Plant Biology

    Natural genetic variation underlying the negative effect of elevated CO2 on ionome composition in Arabidopsis thaliana

    Oceane Cassan, Lea-Lou Pimpare ... Antoine Martin
    Plants show a high level of genetic diversity in their response to elevated CO2, suggesting the presence of genetic mechanisms that will allow them to adapt to this environmental change.
    1. Biochemistry and Chemical Biology

    Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

    Zheng Ruan, Junuk Lee ... Wei Lü
    A comprehensive analysis questioned the prevailing views of Src-mediated hPANX1 phosphorylation at Tyr199 and Tyr309.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

    Samuel C Griffiths, Jia Tan ... Hsin-Yi Henry Ho
    Structure-function analysis of the ROR2 cysteine-rich domain reveals a new mechanism of WNT5A reception at the cell surface and provides new insights into the pathogenic mechanisms of Robinow syndrome-driving ROR2 mutations.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji
    Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.
    1. Computational and Systems Biology
    2. Cancer Biology

    Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

    Khanh N. Dinh, Monika K. Kurpas, Marek Kimmel
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Immunology and Inflammation

    Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

    Tobias Weinberger, Messerer Denise ... Christian Schulz
    In cardiac ischemia/reperfusion injury, resident macrophages orchestrate the immune response and positively influence postinfarct remodeling, whereas recruited macrophages determine infarct size.
    1. Cell Biology
    2. Developmental Biology

    Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

    Corey D Holman, Alexander P Sakers ... Patrick Seale
    Single-cell expression profiling and genetic lineage analysis show that aging impairs adipocyte differentiation from precursor cells and blocks the thermogenic activation of adipocytes during cold exposure.
    1. Neuroscience

    Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain

    Ya-Hui Lin, Li-Wen Wang ... Li-An Chu
    A new approach uses heat-induced antigen retrieval to enable tissue clearing, multiple-round immunostaining, and expansion microscopy for volumetric imaging of centimeter-scale clinical formalin-fixed paraffin-embedded specimens.
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Immunology and Inflammation

    UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

    Mykhailo Vladymyrov, Luca Marchetti ... Britta Engelhardt
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

    Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani ... Martin Dresler
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Olfactory ensheathing cells are hybrid glial cells that promote neural repair

    Patricia E. Phelps, Sung Min Ha ... Xia Yang
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Extant cartilaginous fishes share trabecular and areolar mineralization patterns, but not tesserae, and evidence for a paedomorphic chimaera skeleton

    Oghenevwogaga J. Atake, Fidji Berio ... B. Frank Eames
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    A packaging signal-binding protein regulates the assembly checkpoint of integrative filamentous phages

    Ting-Yu Yeh, Michael C. Feehley ... Gregory P. Contreras
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Contribution of the epididymis beyond fertilization: relevance of CRISP1 and CRISP3 for sperm DNA integrity and early embryo development

    Sulzyk Valeria, Curci Ludmila ... Patricia S Cuasnicu
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K. Alexander, Karina F. Rodriguez ... Humphrey Hung-Chang Yao
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Mapping Spatial Patterns to Energetic Benefits in Groups of Flow-coupled Swimmers

    Sina Heydari, Haotian Hang, Eva Kanso
    Revised
    Reviewed Preprint v2
    1. Immunology and Inflammation

    Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2

    Tong Feng, Qi Zhang ... Qiao-Feng Wu
    Serum exosomal sequencing combined with cell and animal experiments indicate that miRNA-199b-5p is a novel miRNA associated with osteoarthritis (OA) and can modulate the onset and progression of the disease.
    1. Cell Biology

    Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

    Tongtong Ma, Ruimin Ren ... Heng Wang
    Efficient myogenic and lipogenic transdifferentiation of chicken fibroblasts in 3D culture produces meat with precisely controlled levels of intramuscular fat and extracellular matrix.
    1. Neuroscience

    A fear conditioned cue orchestrates a suite of behaviors in rats

    Amanda Chu, Nicholas T Gordon ... Michael A McDannald
    Comprehensive behavioral ethograms reveal a fear conditioned cue to elicit a temporally organized suite of behaviors spanning freezing, locomotion, rearing, and jumping.
    1. Microbiology and Infectious Disease

    Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

    Tomoko Kubori, Kohei Arasaki ... Hiroki Nagai
    Interplay between multiple Legionella pneumophila effector proteins lead to spatial and temporal regulation of the host Rab10 localization to the bacterial vacuole by controlling noncanonical ubiquitin modifications.
    1. Immunology and Inflammation
    2. Cancer Biology

    An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

    Lilong Liu, Zhenghao Liu ... Zheng Liu
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Medicine

    Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

    Lianlei Wang, Sen Zhao ... Nan Wu
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Clearance of protein aggregates during cell division

    Shoukang Du, Yuhan Wang ... Ting Gang Chew
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

    Dilara N. Anbarci, Jennifer McKey ... Blanche Capel
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A ventral hippocampal-lateral septum pathway regulates social novelty preference

    Maha Rashid, Sarah Thomas ... Malavika Murugan
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Engineered Migrasomes: A Robust, Thermally Stable Vaccination Platform

    Dongju Wang, Haifang Wang ... Zhihua Liu
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Calorie Restriction: A Randomized Controlled Trial

    Isabell Wilming, Jana Tuschewski ... Dominic Landgraf
    Revised
    Reviewed Preprint v2
    1. Microbiology and Infectious Disease

    Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

    Cenk Celik, Stella Tue Ting Lee ... Guillaume Thibault
    Enterococcus faecalis infection elicits a cellular response marked by novel bacterial-host interactions, revealing insights into immune evasion mechanisms in chronic wound infections.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis facilitates functional evolution in an ancient transcription factor

    Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton
    A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
    1. Neuroscience

    Visual to default network pathways: A double dissociation between semantic and spatial cognition

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

    Hsiao-Fen Han, Shao-Fu Nien ... Yi-Chun Wu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

    Zak Buhmann, Amanda K. Robinson ... Reuben Rideaux
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Frequency-specific cortico-subcortical interaction in continuous speaking and listening

    Omid Abbasi, Nadine Steingräber ... Joachim Gross
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Effort Drives Saccade Selection

    Damian Koevoet, Laura Van Zantwijk ... Christoph Strauch
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cortical beta oscillations map to shared brain networks modulated by dopamine

    Meera Chikermane, Liz Weerdmeester ... Wolf-Julian Neumann
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

    Gang Liu, Yunxuan Hou ... Xiumei Jiang
    HSCB could be activated by PI3K signaling to facilitate FOG1 nuclear translocation to promote human erythropoiesis and megakaryopoiesis, highlighting an important, previously unrecognized iron–sulfur cluster delivery independent function of HSCB.
    1. Neuroscience

    FMRP regulates postnatal neuronal migration via MAP1B

    Salima Messaoudi, Ada Allam ... Isabelle Caille
    A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
    1. Developmental Biology

    Cytoneme-mediated intercellular signaling in keratinocytes essential for epidermal remodeling

    Yi Wang, Qingan He ... Dae Seok Eom
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

    Yan-Xue Li, Xin-Le Kang ... Xiao-Fan Zhao
    Revised
    Reviewed Preprint v2
    1. Ecology
    2. Epidemiology and Global Health

    Landscape drives zoonotic malaria prevalence in non-human primates

    Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace
    Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
    1. Stem Cells and Regenerative Medicine

    Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

    Jing-Ping Wang, Chun-Hao Hung ... C-K James Shen
    The anti-cancer or lifespan extension properties of a novel genetically engineered hematopoietic blood system could be transferred horizontally in mice, which suggests a new direction of biomedical research for anti-aging/antidisease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala
    During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.
    1. Physics of Living Systems

    The younger flagellum sets the beat for Chlamydomonas reinhardtii

    Da Wei, Greta Quaranta ... Daniel SW Tam
    External hydrodynamic forcing on each flagellum of Chlamydomonas reinhardtii reveals a leader-follower relation between the two flagella in the synchronous beating.
    1. Epidemiology and Global Health

    Misstatements, misperceptions, and mistakes in controlling for covariates in observational research

    Xiaoxin Yu, Roger S Zoh ... David B Allison
    This quick reference guide for researchers addresses common misconceptions in the use of covariates in observational research and offers tips for preventing misstatements and mistakes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

    Yongjin Liu, Sandra LaBonte ... Paul D. Straight
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

    Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Functional diversity of dopamine axons in prefrontal cortex during classical conditioning

    Kenta Abe, Yuki Kambe ... Tatsuo Sato
    Two-photon calcium imaging revealed that many mesocortical dopamine axons show enhanced selectivity for aversive cue processing during classical conditioning.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Deciphering the chemical language of inbred and wild mouse conspecific scents

    Maximilian Nagel, Marco Niestroj ... Marc Spehr
    Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.
    1. Cancer Biology

    Overcoming the nutritional immunity by engineering iron-scavenging bacteria for cancer therapy

    Sin-Wei Huang, See-Khai Lim ... Kurt Yun Mou
    Bacterial therapy can be impeded by nutrition deprivation in the tumor microenvironment, and enhancing bacteria resistance to iron sequestration enhances its antitumoral activity for therapeutic purposes.
    1. Neuroscience

    Jointly looking to the past and the future in visual working memory

    Baiwei Liu, Zampeta-Sofia Alexopoulou, Freek van Ede
    When memorising dynamic visual objects, the brain codes for both the past and the anticipated future object location and co-activates both codes when selecting memories for guiding behaviour.
    1. Neuroscience

    Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'

    James Taniguchi, Riccardo Melani ... Nicolas X Tritsch
    We are writing to comment on the article by Mohebi et al., 2023: we show that blue light alters the fluorescent properties of a genetically-encoded dopamine sensor in a manner that may be misconstrued as phasic dopamine release.
    1. Developmental Biology

    FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis

    Meng-Hao Pan, Kun-Huan Zhang ... Shao-Chen Sun
    FMNL2 associates with Formin2 and Arp2/3 complex for actin assembly, which further regulates spindle migration and INF2/Cofilin-related organelle dynamics during mammalian oocyte maturation.
    1. Cell Biology

    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors

    Jun Yang, Shitian Zou ... Xiaochun Bai
    Mecp2 expression is cell cycle-dependent and negatively regulates quiescence exit.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

    Claudia D Consalvo, Adedeji M Aderounmu ... Brenda L Bass
    Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.
    1. Genetics and Genomics

    A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

    Fan Zhang, Annie Lee ... Hong Xu
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipitò ... Christopher A. Reynolds
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

    Laxmi Rathor, Shayla Curry ... Sung Min Han
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Anti-drift pose tracker (ADPT): A transformer-based network for robust animal pose estimation cross-species

    Guoling Tang, Yaning Han ... Pengfei Wei
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

    Xiang Mou, Daoyun Ji
    Not revised
    Reviewed Preprint v1
    1. Ecology
    2. Physics of Living Systems

    Evidence of social learning across symbolic cultural barriers in sperm whales

    Antonio Leitao, Maxime Lucas ... Giovanni Petri
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

    Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson
    A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
    1. Evolutionary Biology

    CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues

    Raphael Aguillon, Mieka Rinsky ... Oren Levy
    Disruption of the Clock gene in the cnidarian Nematostella vectensis revealed its essential role in circadian rhythm maintenance and uncovered a compensatory light-response pathway, advancing our comprehension of circadian regulation in non-bilaterian animals.
    1. Computational and Systems Biology

    Phantasus, a web application for visual and interactive gene expression analysis

    Maksim Kleverov, Daria Zenkova ... Alexey A Sergushichev
    Phantasus democratizes gene expression analysis, offering intuitive and interactive tools that streamline the exploration and analysis of user-provided data and over 96,000 public datasets.
    1. Neuroscience

    Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury

    Sara Bolívar, Elisenda Sanz ... Esther Udina
    In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.
    1. Cancer Biology

    Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    Kyle Spinler, Michael Hamilton ... Tannishtha Reya
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

    Amélie-Rose Boudjema, Rémi Balagué ... Alice Meunier
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Neuroscience

    Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    Jiro Yoshino, Sonali S. Mali ... Jay Z. Parrish
    Not revised
    Reviewed Preprint v1
    1. Stem Cells and Regenerative Medicine

    Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Non-autonomous cell redox-pairs dictate niche homeostasis in multi-lineage stem populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Inferring control objectives in a virtual balancing task in humans and monkeys

    Mohsen Sadeghi, Reza Sharif Razavian ... Dagmar Sternad
    A virtual balancing task with parallel experiments on human and non-human primates revealed a spectrum of behaviors (classified by a computational model into position, velocity, or mixed control strategy) that can serve as basis for analyzing neural population dynamics.
    1. Neuroscience

    Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

    Yiyi Chen, Laimdota Zizmare ... Christoph Trautwein
    Targeted manipulations on organotypic cultures show that the retina switches between at least four different metabolic pathways, each with different yields and kinetics, to dynamically adapt to momentaneous energy needs.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

    Hina Khan, Partha Paul ... Dibyendu Sarkar
    In a stress-specific manner, Mycobacterium tuberculosis PhoP regulates Rv0805 phosphodiesterase expression to control cAMP level and contributes to intracellular survival of the bacilli.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    CoCoNuTs are a diverse subclass of Type IV restriction systems predicted to target RNA

    Ryan T Bell, Harutyun Sahakyan ... Eugene V Koonin
    Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.
    1. Cancer Biology

    Replication of null results: Absence of evidence or evidence of absence?

    Samuel Pawel, Rachel Heyard ... Leonhard Held
    Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
    1. Cancer Biology
    2. Cell Biology

    mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

    Dongyue Jiao, Huiru Sun ... Kun Gao
    Overexpression of inhibitor of Bruton's tyrosine kinase contributes to the process of tumorigenesis by amplifying translation, represents a promising target for anti-cancer therapies.
    1. Immunology and Inflammation

    SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

    Jarno Mäkelä, Alexandros Papagiannakis ... Christine Jacobs-Wagner
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

    Nasim Saadat, Rhys N. Colson ... Peter R. Boag
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dynamic reinforcement learning reveals time-dependent shifts in strategy during reward learning

    Sarah Jo C Venditto, Kevin J Miller ... Nathaniel D Daw
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Neuroscience

    Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    Yunlu Xue, Yimin Zhou, Constance L Cepko
    Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
    1. Developmental Biology

    Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

    Rieko Asai, Vivek N Prakash ... Takashi Mikawa
    At the onset of gastrulation, primitive streak morphogenesis that requires mitosis along the embryo midline, persists even with a disrupted bilateral cell flow.
    1. Evolutionary Biology
    2. Neuroscience

    Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems

    Daniel Thiel, Luis Alfonso Yañez Guerra ... Gáspár Jékely
    The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

    F Javier DeHaro-Arbona, Charalambos Roussos ... Sarah Bray
    Live imaging of the Notch co-activator Mastermind reveals that it promotes the formation of a dynamic transcription hub in Notch ON nuclei, conferring probabilistic transcription and providing a template for signal memory.
    1. Neuroscience

    Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

    Juan Jose Rodriguez Gotor, Kashif Mahfooz ... John F Wesseling
    Reevaluation of reserve synaptic vesicle pools supports a new model of presynaptic function.
    1. Neuroscience

    Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats

    Silvia Cardani, Tara A Janes ... Silvia Pagliardini
    Knockdown of PHOX2B in the chemosensitive area of the retrotrapezoid nucleus of adult rats reduces CO2 responses and the expression of the proton sensors TASK2 and GPR4.
    1. Developmental Biology

    Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
    Revised
    Reviewed Preprint v2
    1. Chromosomes and Gene Expression

    Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

    Yi Fu, Tianxiao Zhao ... Timothée Lionnet
    Revised
    Reviewed Preprint v2
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

    Brennan W. McFarland, HyoJong Jang ... Catherine R. von Reyn
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex

    Claire Meissner-Bernard, Friedemann Zenke, Rainer W. Friedrich
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The decoding of extensive samples of motor units in human muscles reveals the rate coding of entire motoneuron pools

    Simon Avrillon, François Hug ... Dario Farina
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

    Jan Stuchly, David Novak ... Tomas Kalina
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

    Kristin Nordin, Robin Pedersen ... Alireza Salami
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

    Sophie Leclercq, Hany Ahmed ... Nathalie M Delzenne
    Revised
    Reviewed Preprint v2
    1. Evolutionary Biology

    Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

    Jacob D. Bowman, Neide Silva ... Vincent J. Lynch
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    Balázs István Tóth, Bahar Bazeli ... Thomas Voets
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

    Ziyu Wen, Pingchao Li ... Caijun Sun
    Revised
    Reviewed Preprint v2
    1. Cancer Biology

    Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

    Yiwei Huang, Gujie Wu ... Cheng Zhan
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

    Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins
    Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.
    1. Immunology and Inflammation

    Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

    Phillip A Erice, Xinyan Huang ... Antony Rodriguez
    Mirlet7 functions as a molecular brake of CD8+IL17a+ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).
    1. Cell Biology

    Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile

    Yoko Nakai-Futatsugi, Jianshi Jin ... Masayo Takahashi
    Pigmentation that confers protective function of RPE is not underlaid by a specific gene expression profile, reviled by microscopic imaging together with single-cell RNA sequencing.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA

    Pascal Forcella, Niklas Ifflander ... Verdon Taylor
    Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.
    1. Computational and Systems Biology

    Improved clinical data imputation via classical and quantum determinantal point processes

    Skander Kazdaghli, Iordanis Kerenidis ... Philip Teare
    A new data imputation method that can be implemented quantumly allows for better and more reliable classifications.
    1. Evolutionary Biology

    mirror determines the far posterior domain in butterfly wings

    Martik Chatterjee, Xin Y. Yu ... Robert D. Reed
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Goal-directed motor actions drive acetylcholine dynamics in sensory cortex

    Jing Zou, Jan Willem de Gee ... Samuel Andrew Hires
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Spatially targeted inhibitory rhythms differentially affect neuronal integration

    Drew B. Headley, Benjamin Latimer ... Satish S. Nair
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Cell-cycle and Age-Related Modulations in Mouse Chromosome Stiffness

    Ning Liu, Wenan Qiang ... Huanyu Qiao
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Testing the state-dependent model of subsecond time perception against experimental evidence

    Pirathitha Ravichandran-Schmidt, Joachim Hass
    Not revised
    Reviewed Preprint v1
    1. Plant Biology

    Improving rice drought tolerance through host-mediated microbiome selection

    Alex Styer, Dean Pettinga ... Devin Coleman-Derr
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression

    The role of RNA in the maintenance of chromatin domains as revealed by antibody-mediated proximity labelling coupled to mass spectrometry

    Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani ... Axel Imhof
    Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.
    1. Computational and Systems Biology

    Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

    Antony M Jose
    A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.
    1. Immunology and Inflammation

    Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

    Xiuyuan Lu, Hiroki Hayashi ... Sho Yamasaki
    Clonotypic tracing of SARS-CoV-2–responsive T cells reveals vaccination-induced dominant Tfh clonotypes, not pre-existing T cells, associated with sustained humoral response, and can serve as an index of antigen-specific antibody longevity.
    1. Neuroscience
    2. Computational and Systems Biology

    Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

    Jian Qiu, Margaritis Voliotis ... Martin J Kelly
    Revised
    Reviewed Preprint v3
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

    Ashley L Cook, Surojit Sur ... Nicolas Wyhs
    Revised
    Reviewed Preprint v2
    1. Evolutionary Biology

    The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

    Xuankun Li, Adriana E Marvaldi ... Duane D McKenna
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

    Lian Hollander Cohen, Omer Cohen ... Berta Levavi Sivan
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

    Josse Poppinga, Nolan J. Barret ... Jan R.T. van Weering
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

    Manikrao R. Thakare, Prerana Choudhary ... Gaurav Das
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Cell Biology

    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

    Savvas Nikolaou, Amelie Juin ... Laura M Machesky
    Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.
    1. Neuroscience

    Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

    Geoffroy Delamare, Yosif Zaki ... Claudia Clopath
    Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.
    1. Cell Biology
    2. Neuroscience

    Synapsin E-domain is essential for α-synuclein function

    Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler
    Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
    1. Computational and Systems Biology
    2. Ecology

    Collaborative hunting in artificial agents with deep reinforcement learning

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

    Natalia E Ketaren, Fred D Mast ... John D Aitchison
    High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.
    1. Structural Biology and Molecular Biophysics

    Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

    Nicholas James Ose, Paul Campitelli ... Sefika Banu Ozkan
    Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in order to influence spike protein interaction with human cells, potentially altering the virus's infectivity and immune evasion capabilities.
    1. Neuroscience

    A stochastic world model on gravity for stability inference

    Taicheng Huang, Jia Liu
    Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.
    1. Genetics and Genomics

    Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

    Mohammad Alfatah, Jolyn Jia Jia Lim ... Frank Eisenhaber
    Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.
    1. Biochemistry and Chemical Biology

    Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

    Benjamin R Duewell, Naomi E Wilson ... Scott D Hansen
    Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P3 production during immune cell signaling.
    1. Evolutionary Biology

    Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D Geometric Morphometrics reveals wide-gauge posture as an exaptation for gigantism

    Adrian Paramo Blazquez, Pedro Mocho ... Francisco Ortega
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

    Ankur Sinha, Padraig Gleeson ... R Angus Silver
    Revised
    Reviewed Preprint v2
    1. Computational and Systems Biology
    2. Developmental Biology

    The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

    Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson
    A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.
    1. Neuroscience

    Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex

    Hao Li, Jingyu Feng ... Jufang He
    CCK released from the neural projections from the rhinal cortex to the motor cortex modulates neural plasticity and facilitates motor skill learning.
    1. Neuroscience

    A dynamic neural resource model bridges sensory and working memory

    Ivan Tomić, Paul M Bays
    Psychophysical measurement and computational modeling show that sensory information cannot contribute directly to a cognitive judgment, but must first be integrated into resource-limited working memory.
    1. Neuroscience

    Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making

    Mariann Oemisch, Hyojung Seo
    The NMDA receptor might preferentially mediate immediate experience/impact of events with negative over positive valence.
    1. Genetics and Genomics
    2. Neuroscience

    Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

    Céline Petitgas, Laurent Seugnet ... Serge Birman
    Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
    1. Medicine

    Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies

    Sami Fawaz, Severine Marti ... Thierry Couffinhal
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

    Carola Maria Morell, Samantha Grace Tilson ... Ludovic Vallier
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility

    Shahriar Mowla, Linda Farahani ... Channa N Jayasena
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Genetics and Genomics

    The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

    Adam D. Longhurst, Kyle Wang ... David P. Toczyski
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Semantic relatedness proactively benefits learning, memory, and interdependence across episodes

    Kelly A Bennion, Jade Phong ... James W Antony
    Revised
    Reviewed Preprint v2
    1. Computational and Systems Biology

    Predicting metabolic modules in incomplete bacterial genomes with MetaPathPredict

    David Geller-McGrath, Kishori M Konwar ... Jason E McDermott
    MetaPathPredict is a novel bioinformatics tool that makes accurate predictions of KEGG module presence within highly incomplete bacterial genomes.
    1. Cell Biology

    Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

    Rita De Gasperi, Laszlo Csernoch ... Christopher P Cardozo
    Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.
    1. Neuroscience

    Representational drift as a result of implicit regularization

    Aviv Ratzon, Dori Derdikman, Omri Barak
    Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
    1. Structural Biology and Molecular Biophysics

    The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

    Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
    Transient and weak interactions between the substrate-binding proteins of the ATP-binding cassette transporter OpuA can influence the transport efficiency.
    1. Evolutionary Biology

    A direct experimental test of Ohno’s hypothesis

    Ljiljana Mihajlovic, Bharat Ravi Iyengar ... Yolanda Schaerli
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

    Senem Ntourmas, Martin Sachs ... Dominic B Bernkopf
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

    Xiaoning Gao, WuYan Guo ... Jun Kang
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    The actomyosin system is essential for the integrity of the endosomal system in bloodstream form Trypanosoma brucei

    Fabian Link, Sisco Jung ... Brooke Morriswood
    Revised
    Reviewed Preprint v2
    1. Developmental Biology

    Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    Alexandra V. Bruter, Ekaterina A. Varlamova ... Victor V. Tatarskiy
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    CD81+ fibroblasts, a unique subpopulation with accelerated cellular senescence, exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

    Liangliang Fu, Chenghu Yin ... Haibin Xia
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut

    Yueliang Zhang, Yongjun Li ... Amita Sehgal
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity

    Andrew E Worthy, JoAnna T Anderson ... Francisco J Alvarez
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics

    CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples

    Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

    Toshiki Kobayashi, Daichi Nozaki
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

    Qian Wang, Jinxin Liu ... Qian Liu
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

    Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

    Ruichen Yang, Hongshang Chu ... Baojie Li
    Uncovering a new function of BMP signaling and enhancing our comprehension of the pathogenesis of microtia.
    1. Genetics and Genomics

    Mono-methylated histones control PARP-1 in chromatin and transcription

    Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
    Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
    1. Medicine

    Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

    Peigen Chen, Haicheng Chen ... Xing Yang
    Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Experimental evolution for the recovery of growth loss due to genome reduction

    Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
    Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.

Magazine

  1. Episode 92: April 2024

    1. Cell Biology

    Muscle Cells: Tailoring the taste of cultured meat

    Gyuhyung Jin, Xiaoping Bao
    1. Structural Biology and Molecular Biophysics

    Signaling: The tale of capturing Norrin

    Hsin-Yi Henry Ho
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Biosynthesis: RAMPing up knowledge of the translocon

    Dimitrios Vismpas, Friedrich Förster
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Disease Surveillance: Monitoring livestock pregnancy loss

    Clara Akpan
    1. Cancer Biology
    2. Cell Biology

    Exosomes: How tumors escape the immune system

    Stefanie Schmieder
    1. Evolutionary Biology

    Circadian Rhythms: Cnidarians are CLOCKing in

    Erica R Kwiatkowski, Patrick Emery
  8. Image ALT text: Line drawing of a human figure sitting on a stylised brain, in front of white sparks on a yellow background. Vicky Bowskill (CC BY-NC-ND 4.0)

    Neurodiversity in Academia: Time to rethink Tourette’s syndrome

    1. Developmental Biology
    2. Physics of Living Systems

    Morphogenesis: The enigma of cell intercalation

    Raphaël Clément
    1. Neuroscience

    Cognitive Neuroscience: Memorable first impressions

    Emilio Salinas, Bashirul I Sheikh