July 2024

Cover articles

  1. How and why eLife selects papers for peer review

    eLife Editorial Leadership, eLife Senior Editors, eLife Early Career Advisory Group
    1. Cell Biology
    2. Physics of Living Systems

    Water influx helps cells migrate

    Tamas L Nagy, Evelyn Strickland, Orion D Weiner
    1. Neuroscience

    Decoding spike signatures

    Meike E van der Heijden, Amanda M Brown ... Roy V Sillitoe
    1. Neuroscience

    Targeting axo-axonic cells

    Ricardo Raudales, Gukhan Kim ... Z Josh Huang

Highlights controls:

Research articles

    1. Neuroscience

    A toolbox for genetic targeting of the claustrum

    Joël Tuberosa, Madlaina Boillat ... Ivan Rodriguez
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells

    Yuqing Zhu, Kevin Cho ... James B Skeath
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Evolutionary Biology

    The integrated WF-Haldane (WFH) model of genetic drift resolving the many paradoxes of molecular evolution

    Yongsen Ruan, Xiaopei Wang ... Chung-I Wu
    Revised
    Reviewed Preprint v2
    1. Medicine

    A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    Tumininu S Faniyan, Xinyi Zhang ... Kavaljit H Chhabra
    Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

    Sandeep K Ravala, Sendi Rafael Adame-Garcia ... John JG Tesmer
    P-Rex1 adopts an inactive, compact conformation that is stabilized by an abundant intracellular molecule and undergoes dynamic changes to extend upon encountering signaling phospholipids in membranes.
    1. Immunology and Inflammation

    Amphibian mast cells serve as barriers to chytrid fungus infections

    Kelsey A Hauser, Christina N Garvey ... Leon Grayfer
    Enriching amphibian, Xenopus laevis, cutaneous mast cells confers protection against Batrachochytrium dendrobatidis chytrid fungus infections.
    1. Neuroscience

    A split-GAL4 driver line resource for Drosophila CNS cell types

    Geoffrey W Meissner, Allison Vannan ... FlyLight Project Team
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Neuroscience

    Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

    Suguru Takagi, Shiina Takano ... Akinao Nose
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A temporally restricted function of the Dopamine receptor Dop1R2 during memory formation

    Jenifer C Kaldun, Cornelia Fritsch ... Simon G Sprecher
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Detecting directed motion and confinement in single-particle trajectories using hidden variables

    François Simon, Guillaume Ramadier ... Lucien E Weiss
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

    Hannah Bos, Christoph Miehl ... Brent Doiron
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology

    A robust method for measuring aminoacylation through tRNA-Seq

    Kristian Davidsen, Lucas B Sullivan
    Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.
    1. Neuroscience

    MotorNet, a Python toolbox for controlling differentiable biomechanical effectors with artificial neural networks

    Olivier Codol, Jonathan A Michaels ... Paul L Gribble
    MotorNet is a Python toolbox for training artificial neural networks to control arbitrarily complex, differentiable, and biomechanically realistic musculo-skeletal effectors on user-defined sensorimotor tasks.
    1. Structural Biology and Molecular Biophysics

    Divergent folding-mediated epistasis among unstable membrane protein variants

    Laura M Chamness, Charles P Kuntz ... Jonathan P Schlebach
    Many of the synergistic interactions between mutations are modified in the context of unstable proteins in a manner that depends on how the variants promote misfolding in the cell.
    1. Cell Biology

    Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes

    Elizabeth A Beath, Cynthia Bailey ... Francis J McNally
    Limiting cytoplasmic streaming contributes to maintaining spatial separation of the sperm contents from the female meiotic spindle after fertilization.
    1. Neuroscience

    Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes

    Yelyzaveta Bessonova, Baranidharan Raman
    Electrophysiological and behavioral analyses of odor-evoked responses in the locust olfactory system reveal how serotonin uniformly modifies spontaneous and odor-evoked neural activity and yet drive odor-specific changes in behavioral outcomes.
    1. Neuroscience

    Investigating working memory updating processes of the human subcortex using 7 Tesla fMRI

    Anne C Trutti, Zsuzsika Sjoerds ... Birte U Forstmann
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Transdiagnostic compulsivity is associated with reduced reminder setting, only partially attributable to overconfidence

    Annika Boldt, Celine A. Fox ... Sam Gilbert
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Statistics of C. elegans turning behavior reveals optimality under biasing constraints

    W. Mathijs Rozemuller, Steffen Werner ... Thomas S. Shimizu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

    Andrea Vecchione, Mohsen Khosravi-Maharlooei ... Megan Sykes
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Ecology

    Interdependence between SEB-3 and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

    Kathleen T Quach, Gillian A Hughes, Sreekanth H Chalasani
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    Igor Kondrychyn, Haymar Wint ... Li-Kun Phng
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

    Katherine R Cording, Emilie M Tu ... Helen S Bateup
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremor

    Meike E van der Heijden, Amanda M Brown ... Roy V Sillitoe
    Ataxia, dystonia, and tremor phenotypes have distinct and generalizable cerebellar interposed nucleus spike signatures in mice, with defining features identified using a classifier model and pathogenicity tested using optogenetic manipulations.
    1. Cell Biology

    A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

    Joanne Tung, Lei Huang ... Adriana Ordonez
    Calreticulin, beyond its known role as a chaperone, also serves as an endoplasmic reticulum repressor of ATF6⍺, selectively regulating one arm of the unfolded protein response.
    1. Neuroscience

    Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
    A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    Peng Xie, Xu Jiang ... Chengqi Lin
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition

    Yuhkoh Satouh, Takaki Tatebe ... Ken Sato
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

    Yury S Bykov, Solène Zuttion ... Maya Schuldiner
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Structure, dynamics, coding and optimal biophysical parameters of efficient excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Specific Sensitivity to Rare and Extreme Events: Quasi-Complete Black Swan Avoidance vs Partial Jackpot Seeking in Rat Decision-Making

    Mickaël Degoulet, Louis-Matis Willem ... Patrick A Pintus
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

    Katerina Rademacher, Zak Doric ... Ken Nakamura
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

    Ellie I James, David W Baggett ... Abhinav Nath
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Sequential Temporal Anticipation Characterized by Neural Power Modulation and in Recurrent Neural Networks

    Xiangbin Teng, Ru-Yuan Zhang
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Genetics and Genomics

    Impact of Maximal Overexpression of a Non-toxic Protein on Yeast Cell Physiology

    Yuri Fujita, Shotaro Namba, Hisao Moriya
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Tonotopy is not preserved in a descending stage of auditory cortex

    Miaoqing Gu, Shanshan Liang ... Xiaowei Chen
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish

    Evan Lloyd, Fanning Xia ... Alex C Keene
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The scheduling of adolescence with Netrin-1 and UNC5C

    Daniel Hoops, Robert Kyne ... Cecilia Flores
    Adolescent brain development involves dopamine axon growth and a coincident change in UNC5c receptor expression, both of which are responsive, in unison, to an environmental signal.
    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Immunology and Inflammation

    RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia

    Xiaozhuo Yu, Wen Zhou ... Yanhong Ji
    Non-core RAG regions, especially RAG1, maintain V(D)J recombination accuracy and genomic stability, reducing malignant characteristics and off-target recombination in BCR-ABL1+ B-cell acute lymphoblastic leukemia.
    1. Neuroscience

    Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness

    Baba Yogesh, Georg B Keller
    Locomotion triggers a binary state transition in cortical acetylcholine levels that increase top-down and bottom-up responses in layer 5 but not layer 2/3 neurons.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Real-time transcriptomic profiling in distinct experimental conditions

    Tamer Butto, Stefan Pastore ... Susanne Gerber
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Single-Cell and Spatial Transcriptomic Analyses Reveals the Dynamic Transcript Profiles of Myocardial Lymphangiogenesis post Myocardial Infarction

    Jiaqi He, Dali Zhang ... Yaling Han
    Revised
    Reviewed Preprint v3
    1. Plant Biology

    Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

    Maryam Rahmati Ishka, Hayley Sussman ... Magdalena M Julkowska
    Revised
    Reviewed Preprint v2
    1. Developmental Biology

    Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

    Yifan Wu, Kunhua Qin ... Pei Wang
    Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification

    Nikola Sekulovski, Jenna C Wettstein ... Kenichiro Taniguchi
    Analyses of transcriptomic dynamics in a new model of human amnion formation identify five continuous amniogenic transcriptional phases as well as a critical role of TFAP2A in amnion fate progression.
    1. Developmental Biology
    2. Neuroscience

    Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

    Jingjing Liu, Yuedong Wang ... Yao Tian
    Dynamic local microenvironments in Drosophila facilitate axonal projection direction transitions in the absence of clear landmarks.
    1. Cancer Biology
    2. Cell Biology

    A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

    Alex Weiss, Cassandra D'Amata ... Madeline N Hayes
    Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.
    1. Neuroscience
    2. Computational and Systems Biology

    Switching perspective: Comparing ground-level and bird’s-eye views for bees navigating clutter

    Annkathrin Sonntag, Odile Sauzet ... Olivier Bertrand
    Not revised
    Reviewed Preprint v1
    1. Stem Cells and Regenerative Medicine

    Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

    Bethany Moyse, Joanna Moss ... Rebecca J Richardson
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mapping Serotonergic Dynamics using Drug-Modulated Molecular Connectivity

    Tudor M Ionescu, Mario Amend ... Kristina Herfert
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

    Justine Bajohr, Erica Y Scott ... Maryam Faiz
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Salmonids elicit an acute behavioral response to heterothermal environments

    Robert Naudascher, Stefano Brizzolara ... Roman Stocker
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice

    Justin Burdge, Anissa Jhumka ... Ishmail Abdus-Saboor
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multiwell format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    PIM kinase control of CD8 T cell protein synthesis and cell trafficking

    Julia M Marchingo, Laura Spinelli ... Doreen A Cantrell
    Not revised
    Reviewed Preprint v1
    1. Plant Biology

    Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

    Yaning Cui, Hongping Qian ... Jinxing Lin
    The phosphorylation of FLS2 may activate flg22-triggered immunity by facilitating the partitioning of FLS2 into functional AtRem1.3-associated nanodomains.
    1. Cancer Biology

    YAP/TAZ enhances P-body formation to promote tumorigenesis

    Xia Shen, Xiang Peng ... Chen-Ying Liu
    P-body is a new downstream effector of YAP/TAZ for tumorigenesis and tumor progression, suggesting disruption of P-bodies as a potential therapeutic strategy for tumors with active YAP.
    1. Microbiology and Infectious Disease

    Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

    Hideo Fukuhara, Kohei Yumoto ... Katsumi Maenaka
    X-ray crystallographic and atomic force microscopic analyses reveal the tilted homodimer structure and unanticipated dynamic characteristics of canine distemper virus-hemagglutinin (CDV-H), providing insights into the molecular and dynamic processes of Morbillivirus for cell entry, effective immunizations, and vaccine/drug design.
    1. Ecology

    Landing force reveals new form of motion-induced sound camouflage in a wild predator

    Kim Schalcher, Estelle Milliet ... Emily LC Shepard
    Bio-logging reveals that barn owls enhance hunting success by using man-made poles to silently approach their prey, emphasizing a link between predator-prey interactions and land-use in the agricultural landscape.
    1. Neuroscience

    Shared structure facilitates working memory of multiple sequences

    Qiaoli Huang, Huan Luo
    Common cognitive maps across feature dimensions are spontaneously leveraged to facilitate storage of multiple sequences via compressed encoding and neural replay in human working memory.
    1. Microbiology and Infectious Disease

    Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance

    Alejandro Prieto, Luïsa Miró ... Antonio Juarez
    A novel strategy to combat antimicrobial resistance has been identified by using vaccines and nanobodies to target specific extracellular proteins located on multiresistant bacterial plasmids.
    1. Neuroscience

    Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

    Sophie Peterson, Amanda Maheras ... Ronald Keiflin
    Rodent model of context-dependent discrimination reveals sex-biased tradeoff between speed of acquisition and robustness of contextual control over cue-elicited reward seeking, linked to orbitofrontal cortex activation.
    1. Cell Biology
    2. Neuroscience

    Presynaptic Rac1 in the hippocampus selectively regulates working memory

    Jaebin Kim, Edwin Bustamante ... Scott H Soderling
    Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.
    1. Neuroscience

    Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

    Mohanakarthik P Nallasivan, Deepanshu ND Singh ... Matthias Soller
    Not revised
    Reviewed Preprint v1
    1. Plant Biology

    Molecular Matchmakers: Phytoplasma Effector SAP54 Targets MADS-Box Factor SVP to Enhance Attraction of Fecund Female Vectors by Modulating Leaf Responses to Male Presence

    Zigmunds Orlovskis, Archana Singh ... Saskia A Hogenhout
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Computational and Systems Biology

    circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA

    Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup ... Christian Kroun Damgaard
    A dysregulated circular RNA in bladder cancer controls oncogenic pathways by tethering specific RNA-binding proteins, which in turn inhibits their normal functions.
    1. Physics of Living Systems

    Optical mapping of ground reaction force dynamics in freely behaving Drosophila melanogaster larvae

    Jonathan H Booth, Andrew T Meek ... Malte C Gather
    A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.
    1. Neuroscience

    Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

    Nicola Masala, Manuel Mittag ... Tony Kelly
    Common adeno-associated viral transduction procedures induce artefactual spatially confined Ca2+ waves in the hippocampus.
    1. Structural Biology and Molecular Biophysics

    The mechanism of mammalian proton-coupled peptide transporters

    Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
    The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
    1. Physics of Living Systems

    Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws

    M Julia Maristany, Anne Aguirre Gonzalez ... Jerelle A Joseph
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Food-washing monkeys recognize the law of diminishing returns

    Jessica E. Rosien, Luke D. Fannin ... Amanda Tan
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Diverse prey capture strategies in teleost larvae

    Duncan S Mearns, Sydney A Hunt ... Herwig Baier
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Computational and Systems Biology

    Multi-omic analysis of bat versus human fibroblasts reveals altered central metabolism

    N Suhas Jagannathan, Javier Yu Peng Koh ... Lisa Tucker-Kellogg
    To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.
    1. Plant Biology

    Unraveling the role of urea hydrolysis in salt stress response during seed germination and seedling growth in Arabidopsis thaliana

    Yuanyuan Bu, Xingye Dong ... Shenkui Liu
    Salt stress triggers excessive hydrolysis of arginine-derived urea in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, providing new insights into the relationship between seed nitrogen mobilization and seed germination inhibition.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

    Zachary H Williams, Alvaro Dafonte Imedio ... Welkin E Johnson
    The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.
    1. Neuroscience

    Firing rate adaptation affords place cell theta sweeps, phase precession, and procession

    Tianhao Chu, Zilong Ji ... Si Wu
    Adaptation within a continuous attractor neural network explains theta phase precession and procession, providing insight into the neural mechanism of theta phase coding in the hippocampus.
    1. Neuroscience

    Speech and music recruit frequency-specific distributed and overlapping cortical networks

    Noémie te Rietmolen, Manuel R Mercier ... Daniele Schön
    The neural response to natural speech and music processing is mostly shared between the domains, with additional evidence for selectivity in distributed (i.e. not regional) and frequency-specific neural activity.
    1. Medicine

    Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

    Christin Krause, Jan H Britsemmer ... Henriette Kirchner
    The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
    1. Neuroscience

    Using synchronized brain rhythms to bias memory-guided decisions

    John J Stout, Allison E George ... Amy L Griffin
    Brain-machine interfacing was used to align trials with heightened prefrontal-hippocampal oscillatory synchronization on spatial working memory-dependent and -independent tasks, and these trials were associated with correct choices.
    1. Developmental Biology
    2. Neuroscience

    Energetic demands regulate sleep-wake rhythm circuit development

    Amy R Poe, Lucy Zhu ... Matthew S Kayser
    Behavioral and circuit analyses show that changes to energetic demand are a key driver of consolidation of daily sleep and feeding patterns as animals mature.
    1. Neuroscience

    Neural activity ramps in frontal cortex signal extended motivation during learning

    Josue M Regalado, Ariadna Corredera Asensio ... Priyamvada Rajasethupathy
    Motivated animals learn to put in more effort and ignore distractions to reach their goals due to increased neural activity in the frontal cortex.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

    Filip Knop, Apolena Zounarová ... Marie Macůrková
    The SEL-5/AAK1 kinase unexpectedly influences Wnt signalling-dependent processes in a multicellular organism without using its enzymatic activity.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

    Katarzyna Marta Zoltowska, Utpal Das ... Lucía Chávez-Gutiérrez
    A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex

    Sara Ibañez, Nilapratim Sengupta ... Christina M Weaver
    Biologically plausible levels of myelin dystrophy induce substantial working memory impairment in a computational model of brain aging across two spatial and temporal scales.
    1. Genetics and Genomics

    Deficiency of IQCH causes male infertility in humans and mice

    Tiechao Ruan, Ruixi Zhou ... Ying Shen
    IQCH is required for acrosome and axoneme development during spermatogenesis in humans and mice.
    1. Neuroscience

    Prediction error determines how memories are organized in the brain

    Nicholas GW Kennedy, Jessica C Lee ... Nathan M Holmes
    When new and past experiences are similar, the memories of those experiences are stored together, and when new and past experiences are different, the memories of those experiences are stored separately.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling

    Henning Mühlenbeck, Yuko Tsutsui ... Cyril Zipfel
    Structure-function analysis reveals an allosteric mechanism activating a plant immune receptor kinase complex.
    1. Neuroscience

    Cell-type-specific fluorescent tagging of endogenous target proteins reveals synaptic enrichment and dynamic regulations of dopamine receptors

    Shun Hiramatsu, Kokoro Saito ... Hiromu Tanimoto
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Neuroscience

    A synergistic workspace for human consciousness revealed by Integrated Information Decomposition

    Andrea I Luppi, Pedro AM Mediano ... Emmanuel A Stamatakis
    Anaesthesia and disorders of consciousness both reduce the capacity of the human brain to integrate information, specifically targeting interactions within a shared circuit of regions in the brain’s default network.
    1. Neuroscience

    Non-Hebbian plasticity transforms transient experiences into lasting memories

    Islam Faress, Valentina Khalil ... Sadegh Nabavi
    The process of transformation of a transient experience into a memory is neither restricted to the time of the experience nor to the synapses triggered by it, but it can be influenced by past and future events.
    1. Cancer Biology

    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

    Pirunthan Perampalam, James I MacDonald ... Frederick A Dick
    Extending the period of remission for cancer patients requires new knowledge of dormant, residual disease and Netrin signaling contributes to the survival of dormant cells in ovarian cancer.
    1. Neuroscience

    Selective consolidation of learning and memory via recall-gated plasticity

    Jack W Lindsey, Ashok Litwin-Kumar
    A theory of memory consolidation illustrates the benefits of communication between short- and long-term memory systems to prioritize the storage of reliable memories.
    1. Neuroscience

    Cortical plasticity is associated with blood–brain barrier modulation

    Evyatar Swissa, Uri Monsonego ... Alon Friedman
    Neuronal activity modulates blood–brain barrier permeability, influencing synaptic plasticity and local network reorganization in the healthy brain.
    1. Neuroscience

    An allocentric human odometer for perceiving distances on the ground plane

    Liu Zhou, Wei Wei ... Zijiang J He
    Fitting our terrestrial niche, the human visual system adopts a ground-based reference frame for spatial computation in concert with the attention, memory, and path-integration processes for space perception during self-motion.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

    Liyi Wang, Shiqi Liu ... Tizhong Shan
    Revised
    Reviewed Preprint v2
    1. Cancer Biology

    Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    Youyou Zhang, Mu Xu ... Lin Zhang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Decoding the Cognitive map: Learning place cells and remapping

    Markus Borud Pettersen, Vemund Sigmundson Schøyen ... Mikkel Elle Lepperød
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

    Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely C Matteucci, Patricia A Assis ... Ricardo T Gazzinelli
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

    Viviane Kremling, Sven Falke ... Janina Sprenger
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models

    Ulrike Pech, Jasper Janssens ... Patrik Verstreken
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

    Chia-Lo Ho, Li-Tzu Yeh ... Huey-Kang Sytwu
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Immunology and Inflammation

    Stimulation-induced cytokine polyfunctionality as a dynamic concept

    Kevin Portmann, Aline Linder, Klaus Eyer
    Resolving parallel and concurrent cytokine secretion is essential to studying polyfunctional cytokine-secreting cells, and to differentiating immune response granularity from unwinding the complexity and heterogeneity of cytokine responses.
    1. Neuroscience

    Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration

    Annette Pisanski, Mitchell Prostebby ... Silvia Pagliardini
    Multivariate analysis of respiratory cycle shows that GABAergic disinhibition in the rostral regions of the lateral parafacial area is linked to the most significant and enduring changes in active expiration.
    1. Neuroscience

    Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions

    Tara Ghafari, Cecilia Mazzetti ... Ole Jensen
    Lateral asymmetry of the globus pallidus, caudate nucleus, and thalamus can predict attention-related modulations of posterior alpha oscillations when combining structural MRI with MEG.
    1. Neuroscience

    A multiplex of connectome trajectories enables several connectivity patterns in parallel

    Parham Mostame, Jonathan Wirsich ... Sepideh Sadaghiani
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

    Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    The impact of different antimicrobial exposures on the gut microbiome in the ARMORD observational study

    Leon Peto, Nicola Fawcett ... A Sarah Walker
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Cancer Biology

    Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

    Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Functional genomics reveals the mechanism of hypoxic adaptation in nontuberculous mycobacteria

    Yoshitaka Tateishi, Yuriko Ozeki ... Sohkichi Matsumoto
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Atomistic Tuning of the GeoCas9 Recognition Lobe Modulates Allosteric Motions and Guide RNA Interactions

    Helen B Belato, Alexa L Knight ... George P Lisi
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Hierarchical cortical entrainment orchestrates the multisensory processing of biological motion

    Li Shen, Shuo Li ... Yi Jiang
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression

    Vandana Singh, Scot P Ouellette
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

    Julia Ruge, Mana R Ehlers ... Tina B Lonsdorf
    Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.
    1. Immunology and Inflammation
    2. Medicine

    Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    Joanna C Porter, Jamie Inshaw ... Venizelos Papayannopoulos
    Nebulized dornase alfa endonuclease reduces inflammation, coagulopathy, and the length of hospitalization in individuals with severe COVID-19 pneumonia.
    1. Cell Biology
    2. Neuroscience

    Translational regulation enhances distinction of cell types in the nervous system

    Toshiharu Ichinose, Shu Kondo ... Hiromu Tanimoto
    Neuronal and glial cells in Drosophila differentiate the translation of neuronal mRNA with upstream open-reading frames.
    1. Medicine

    Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    Ruijie Zeng, Yuying Ma ... Hao Chen
    Proton pump inhibitors are associated with an increased susceptibility to respiratory infections.
    1. Neuroscience

    Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

    Ricardo Raudales, Gukhan Kim ... Z Josh Huang
    A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.
    1. Neuroscience

    Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space

    Hyeri Hwang, Seung-Woo Jin, Inah Lee
    The intermediate region of the hippocampus is critical for strategic goal-directed navigation to the higher-value location, whereas the dorsal hippocampus implements the precise targeting of the goal location.
    1. Neuroscience

    Nonlinear sensitivity to acoustic context is a stable feature of neuronal responses to complex sounds in auditory cortex of awake mice

    Marios Akritas, Alex G Armstrong ... Jennifer F Linden
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Evolutionary Biology

    The Mycobacterium tuberculosis complex pangenome is small and driven by sub-lineage-specific regions of difference

    Mahboobeh Behruznia, Maximillian Marin ... Conor J Meehan
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

    Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Reconstructing Voice Identity from Noninvasive Auditory Cortex Recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

    Ning Song, Hang Gao ... Wenlong Zhang
    Revised
    Reviewed Preprint v3
    1. Neuroscience

    Emotional vocalizations alter behaviors and neurochemical release into the amygdala

    Zahra Ghasemahmad, Aaron Mrvelj ... Jeffrey J Wenstrup
    The modulatory neurochemicals acetylcholine and dopamine are released differentially into the basolateral amygdala depending on the emotional content of vocalizations and the sex, hormonal state, and experience of listening animals.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Enrichment of rare codons at 5' ends of genes is a spandrel caused by evolutionary sequence turnover and does not improve translation

    Richard Sejour, Janet Leatherwood ... Bruce Futcher
    The 5' ends of genes are slightly enriched for rare codons largely because the ends turnover in evolution and gather rare codons, and these rare codons do not improve translation.
    1. Neuroscience

    Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

    Cristina Sáenz de Miera, Nicole Bellefontaine ... Carol F Elias
    Glutamate neurotransmission from hypothalamic ventral premammillary nucleus is indispensable for leptin action in pubertal development and typical reproduction.
    1. Cancer Biology
    2. Cell Biology

    Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

    Camille Dantzer, Justine Vaché ... Violaine Moreau
    Findings identify a new link between oncogenic ß-catenin and exosome biogenesis, which may serve as an important nodal point in the immune escape of hepatocellular carcinoma.
    1. Biochemistry and Chemical Biology

    The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

    Steven W Cummings, Yan Li ... Antonina Roll-Mecak
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

    Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda
    Anatomical study reveals a new perspective on the definition of an electrical synapse where, in addition to the communicating role of gap junctions, additional cellular structures might be involved in the support and regulation of these intercellular channels.
    1. Cell Biology

    Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

    Zhongyun Xie, Yongping Chai ... Wei Li
    Asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
    1. Cancer Biology

    RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

    Fang Huang, Zhenwei Dai ... Yang Wang
    RBM7 functions as a novel regulator of MFGE8 alternative splicing and p65 phosphorylation to counteract the metastatic potential of breast cancer, offering novel mechanistic insights into how abnormal splicing contributes to tumor aggressiveness.
    1. Biochemistry and Chemical Biology

    Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

    Boglarka Zambo, Evelina Edelweiss ... Gergo Gogl
    The SH3 domain of BIN1 mediates an unexpectedly large array of interactions, which is perturbed by missense variants.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

    John C Bowler, George Zakka ... Attila Losonczy
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Human EEG and artificial neural networks reveal disentangled representations of object real-world size in natural images

    Zitong Lu, Julie D Golomb
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    The target of rapamycin signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

    Guoqi Li, Xiaohong Cao ... Shihua Wang
    Exploration of the target of rapamycin pathway in Aspergillus flavus reveals critical regulatory elements influencing aflatoxin synthesis and stress tolerance, offering potential targets for antifungal strategies.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DDX6 regulates translation and decay of inefficiently translated mRNAs

    Ramona Weber, Chung-Te Chang
    DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway.
    1. Medicine

    Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

    Filipa M Lopes, Celine Grenier ... Neil A Roberts
    Proof of concept that viral vector-mediated gene transfer improves bladder function in a preclinical model of an inherited early-onset lower urinary tract disease.
    1. Microbiology and Infectious Disease

    Bacteria are a major determinant of Orsay virus transmission and infection in Caenorhabditis elegans

    Brian G Vassallo, Noemie Scheidel ... Dennis H Kim
    Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.
    1. Neuroscience

    Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening

    Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann
    In vivo calcium imaging in visual cortex neurons before eye opening shows that clustered synaptic inputs develop in dendritic domains, which may be precursors of computational subunits after eye opening.
    1. Neuroscience

    Chronic activation of a negative engram induces behavioral and cellular abnormalities

    Alexandra L Jellinger, Rebecca L Suthard ... Steve Ramirez
    Repeatedly activating negative memory-bearing cells produces cellular and behavioral abnormalities.
    1. Immunology and Inflammation
    2. Cancer Biology

    Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

    Kai Sha, Renyuan Zhang ... John J Krolewski
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Intracellular Expression of a Fluorogenic DNA Aptamer Using Retron Eco2

    Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    NK Cell Exhaustion in Wilson’s Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

    Yong Jin, Jiayu Xing ... Qingsheng Yu
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Evolutionary Biology

    Evolutionary rescue of spherical mreB deletion mutants of the rod-shape bacterium Pseudomonas fluorescens SBW25

    P Richard J Yulo, Nicolas Desprat ... Heather L Hendrickson
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics

    Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

    Hitendra Negi, Aravind Ravichandran ... Ranabir Das
    Biophysical experiments, pulse-chase assays, and molecular dynamics simulations reveal how the proteasome targeting signal Fat10 can modulate the structure of substrate proteins to potentially regulate their degradation by the proteasome.
    1. Neuroscience

    Statistical learning shapes pain perception and prediction independently of external cues

    Jakub Onysk, Nicholas Gregory ... Flavia Mancini
    Statistical learning shapes pain perception by allowing the brain to predict and modulate pain intensity based on temporal patterns, providing insights into pain regulation and their relevance to chronic pain.
    1. Ecology

    Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’

    Jiayun Li, Paul Holford ... Xiaoge Nian
    Molecular mechanism that Candidatus Liberibacter asiaticus improves the lipid metabolism and fecundity of Diaphorina citri through adipokinetic hormone and its receptor.
    1. Developmental Biology

    Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

    Siyuan Cheng, Ivan Fan Xia ... Stefania Nicoli
    Flow hemodynamic activation of endothelial klf2a is a mechanism regulating initial vascular smooth muscle cell differentiation on circle of Willis arteries.
    1. Physics of Living Systems

    Gendered hiring and attrition on the path to parity for academic faculty

    Nicholas LaBerge, Kenneth Hunter Wapman ... Daniel B Larremore
    Achieving gender parity among U.S. tenured and tenure-track faculty will require changes to hiring, which has substantially greater impacts on faculty gender representation than gendered differences in attrition rates.
    1. Neuroscience

    Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance

    Augustine Xiaoran Yuan, Jennifer Colonell ... Timothy D Harris
    Neurons can be tracked in mice implanted with Neuropixels 2.0 probes for up to 8 weeks using visual receptive fields to score tracking in the absence of reference data.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Treacle’s ability to form liquid phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

    Artem K Velichko, Anastasia P Kovina ... Omar L Kantidze
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

    Ismail M Meraz, Mourad Majidi ... Jack A Roth
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Whole-body connectome of a segmented annelid larva

    Csaba Verasztó, Sanja Jasek ... Gáspár Jékely
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

    Rei Yagasaki, Ryo Nakamura ... Yoshiko Takahashi
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

    Hee Young Kim, Yeon Jun Kang ... Won-Woo Lee
    Indoxyl sulfate, a key uremic toxin in chronic kidney disease (CKD), induces trained immunity in monocytes via crosstalk between aryl hydrocarbon receptor (AhR)-dependent epigenetic reprogramming by enhancement of the arachidonic acid pathway and AhR-independent metabolic rewiring.
    1. Medicine

    Tumor purity-related genes for predicting the prognosis and drug sensitivity of DLBCL patients

    Zhenbang Ye, Ning Huang ... Wenting Huang
    A prognostic model constructed based on RNA-sequencing and clinical specimens analyses reveals VCAN, C1QB, and CD3G could be key factors in modulating tumor microenviornment of DLBCL.
    1. Chromosomes and Gene Expression

    Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation

    Marwan Anoud, Emmanuelle Delagoutte ... Jean-Paul Concordet
    When exposed to high-dose ionizing radiation, tardigrades undergo extensive DNA damage, like humans, but cope by stimulating expression of DNA repair proteins and of TDR1, a novel tardigrade-specific DNA-binding protein.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

    Rajdeep Banerjee, Thomas J Meyer ... David D Roberts
    Increased extramedullary erythropoiesis in spleen compensates for the elevated turnover of red blood cells in mice lacking CD47, but extramedullary erythropoiesis is suppressed in mice lacking the CD47 ligand thrombospondin-1.
    1. Neuroscience

    Selective recruitment of the cerebellum evidenced by task-dependent gating of inputs

    Ladan Shahshahani, Maedbh King ... Jörn Diedrichsen
    The human cerebellum shows fMRI activity for many tasks – however, the inputs from the neocortex are upregulated in a task-dependent manner when cerebellar computation is required.
    1. Neuroscience

    Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components

    Mattias Horan, Daniel Regester ... Yoh Isogai
    Reviewed Preprint
    1. Neuroscience

    A direct neural signature of serial dependence in working memory

    Cora Fischer, Jochen Kaiser, Christoph Bledowski
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold

    Victoria Mischley, Johannes Maier ... John Karanicolas
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Individuality across environmental context in Drosophila melanogaster

    Thomas F Mathejczyk, Cara Knief ... Gerit A Linneweber
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Basal ganglia output - entopeduncular nucleus - coding of contextual kinematics and reward in the freely moving mouse

    Anil K Verma-Rodríguez, Josué O Ramírez-Jarquín ... Fatuel Tecuapetla
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Distinct neural mechanisms underlying perceptual and attentional impairments of conscious access

    Samuel Noorman, Timo Stein ... Simon van Gaal
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior

    Alex J Yonk, Ivan Linares-García ... David J Margolis
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales

    Ye Wang, Yinmei Ni ... Jian Li
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mapping patterns of thought onto brain activity during movie-watching

    Raven S Wallace, Brontë Mckeown ... Jonathan Smallwood
    Revised
    Reviewed Preprint v3
    1. Cancer Biology
    2. Immunology and Inflammation

    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

    Nicholas J Mullen, Surendra K Shukla ... Pankaj K Singh
    Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

    Carlo Giannangelo, Matthew P Challis ... Darren J Creek
    M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.
    1. Neuroscience

    Sex-specific resilience of neocortex to food restriction

    Zahid Padamsey, Danai Katsanevaki ... Nathalie L Rochefort
    Multi-scale analysis of mouse visual cortex reveals a sex-specific difference in response to long-term food restriction, with males being more impacted than females.
    1. Chromosomes and Gene Expression

    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

    Joshua D Eaton, Jessica Board ... Steven West
    High-resolution mapping of RNA polymerase II transcripts shows that the directionality of mammalian promoters is determined by preferential transcriptional initiation and the opposing activities of Integrator and CDK9.
    1. Evolutionary Biology

    Early evolution of the ecdysozoan body plan

    Deng Wang, Yaqin Qiang ... Jian Han
    Discovery of new taxon of Saccorhytida suggests that the ground pattern of Ecdysozoa may not be elongated vermiform instead sac-like in shape.
    1. Neuroscience

    EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

    Petteri Stenroos, Isabelle Guillemain ... Emmanuel L Barbier
    Rats with absence epilepsy exhibit hindered and restricted sensory processing during ongoing seizures, as demonstrated by functional magnetic resonance imaging and mean-field simulation studies.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions

    Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site

    Vladimir Khayenko, Cihan Makbul ... Hans M Maric
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Early parafoveal semantic integration in natural reading

    Yali Pan, Steven Frisson ... Ole Jensen
    During natural reading, before we fixate on a word, we can already extract its meaning and even integrate it into the evolving context.
    1. Neuroscience

    Factorized visual representations in the primate visual system and deep neural networks

    Jack W Lindsey, Elias B Issa
    High-level visual cortex and leading neural network models of the visual system retain information about multiple visual scene variables in independent, non-interfering dimensions of their population codes.
    1. Biochemistry and Chemical Biology

    Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

    Ornella Bimai, Ipsita Banerjee ... Derek T Logan
    The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.
    1. Neuroscience

    Mesolimbic dopamine ramps reflect environmental timescales

    Joseph R Floeder, Huijeong Jeong ... Vijay Mohan K Namboodiri
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Evolutionary Biology

    Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency

    Zach Hensel
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    On the nature of the earliest known lifeforms

    Dheeraj Kanaparthi, Frances Westall ... Tillmann Lueders
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neuronal migration depends on blood flow in the adult brain

    Takashi Ogino, Akari Saito ... Kazunobu Sawamoto
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

    Yoshinobu Ichimura, Yuki Sugiura ... Masaaki Komatsu
    Not revised
    Reviewed Preprint v1
    1. Medicine

    An atlas of brain-bone sympathetic neural circuits in mice

    Vitaly Ryu, Anisa Azatovna Gumerova ... Mone Zaidi
    Central SNS outflow sites originating from 87 brain nuclei and sub-nuclei in six brain divisions innervate bone.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum

    Ya-Juan Wang, Xiao-Jing Di ... Ting-Wei Mu
    Hsp47 positively regulates the functional surface expression of endogenous GABAA receptors and plays a critical and general role in the maturation of Cys-loop neuroreceptors.
    1. Cell Biology

    Involvement of TRPV4 in temperature-dependent perspiration in mice

    Makiko Kashio, Sandra Derouiche ... Makoto Tominaga
    TRPV4 and ANO1 are co-expressed in the sweat glands of mouse food pads and found to be involved in perspiration, suggesting that local temperature sensation through TRPV4 could control seating.
    1. Neuroscience

    The breath shape controls intonation of mouse vocalizations

    Alastair MacDonald, Alina Hebling ... Kevin Yackle
    The breathing motor program is re-engaged to control the fluctuations in vocal pitch during a sound.
    1. Neuroscience

    Perceptual error based on Bayesian cue combination drives implicit motor adaptation

    Zhaoran Zhang, Huijun Wang ... Kunlin Wei
    Model based on Bayesian cue combination shows that procedural motor learning is driven by perceptual error in localizing one's effector.
    1. Developmental Biology

    Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development

    Zhimin Xu, Zhao Wang ... Yingchuan B Qi
    The transcriptional activation of the key developmental timer gene, microRNA lin-4, is driven by the transmembrane transcription factor MYRF following its temporally regulated self-cleavage at the cell membrane.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Revised
    Reviewed Preprint v2
    1. Physics of Living Systems

    Feeding Rates in Sessile versus Motile Ciliates are Hydrodynamically Equivalent

    Jingyi Liu, Yi Man ... Eva Kanso
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Neurofeedback training can modulate task-relevant memory replay rate in rats

    Anna K Gillespie, Daniela Astudillo Maya ... Loren M Frank
    A neurofeedback training paradigm provides a new approach to manipulating physiologically relevant hippocampal replay.
    1. Biochemistry and Chemical Biology

    Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

    Hao Wang, Chen Ye ... Yan Li
    Bacterial exonuclease III exhibits underestimated enzymatic activities on single-stranded DNA, which may redefine its roles in relevant biological processes and biosensor development.
    1. Neuroscience

    Goal-directed vocal planning in a songbird

    Anja T Zai, Anna E Stepien ... Richard HR Hahnloser
    Zebra finches are capable of overt vocal planning, but to reach a distant vocal target beyond the range of recently produced pitch requires both practice and auditory feedback.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

    Fayang Zhou, Yuanyuan Zhang ... Qi Hu
    Revised
    Reviewed Preprint v2
    1. Genetics and Genomics

    SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

    Kira Breunig, Xiufen Lei ... Luiz O. F. Penalva
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    A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

    Rachel Pudlowski, Lingyi Xu ... Jennifer T. Wang
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    1. Neuroscience

    Neural Trajectories of Conceptually Related Events

    Matthew Schafer, Philip Kamilar-Britt ... Daniela Schiller
    Not revised
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    1. Neuroscience

    Nutritional state-dependent modulation of Insulin-Producing Cells in Drosophila

    Rituja S Bisen, Fathima Mukthar Iqbal ... Jan M Ache
    Revised
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    1. Immunology and Inflammation

    ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation

    Hyereen Kang, Seong Woo Choi ... Myung-Shik Lee
    The role of lysosomal Ca2+ flux associated with K+ efflux, a well-known event in inflammasome activation in metabolic inflammation and inflammasome activation, has been presented.
    1. Neuroscience

    Hippocampus and striatum show distinct contributions to longitudinal changes in value-based learning in middle childhood

    Johannes Falck, Lei Zhang ... Yee Lee Shing
    Longitudinal and computational analyses reveal an early and temporally stable hippocampal and striatal involvement in reinforcement learning in 6-to-7-year-old children.
    1. Cell Biology
    2. Physics of Living Systems

    Neutrophils actively swell to potentiate rapid migration

    Tamas L Nagy, Evelyn Strickland, Orion D Weiner
    Actin-independent water influx complements actin-driven cytoskeletal forces to potentiate chemoattractant-induced migration in primary human neutrophils.
    1. Neuroscience

    Atypical local and global biological motion perception in children with attention deficit hyperactivity disorder

    Junbin Tian, Fang Yang ... Li Yang
    Children with ADHD exhibit atypical biological motion perception, with local processing related to social interaction skills and global processing showing age-related improvement.
    1. Neuroscience

    Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome

    Amin MD Shakhawat, Jacqueline G Foltz ... Jennifer L Raymond
    The capacity for new cerebellum-dependent learning is influenced by the recent history of neural activity in a mouse model of Fragile X syndrome, suggesting a role for metaplasticity.
    1. Cell Biology
    2. Neuroscience

    Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella

    Liam P. Hallada, Abbas Shirinifard, David J Solecki
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

    Eugine Lee, Zeda Zhang ... Charles L. Sawyers
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

    Caitlin S. Mitchell, Aida Mohammadkhani ... Christopher V. Dayas
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development

    Divyesh Joshi, Preeti Jindal ... Maneesha S. Inamdar
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Ribosomal composition affects the noncanonical translation and toxicity of polyglycine-containing proteins in fragile X-associated conditions

    Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Cancer Biology

    VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300

    Susu Guo, Xiaodi Hu ... Junhao Mao
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

    Ole Bæk, Tik Muk ... Duc Ninh Nguyen
    Revised
    Reviewed Preprint v2
    1. Ecology
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    First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis

    Justine Boutry, Océane Rieu ... Frédéric Thomas
    Revised
    Reviewed Preprint v2
    1. Ecology

    Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

    Xueyou Li, William V Bleisch ... Xue-Long Jiang
    Human disturbance can push mammals together into more frequent encounters and associations.
    1. Cell Biology

    Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

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    Posttranslational modifications of tubulins regulate axonal growth and regeneration by controlling the stabilities of microtubules or modulating their interactions with microtubule-associated proteins.
    1. Biochemistry and Chemical Biology
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    Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity

    Xiaolin Yu, Guangfei Duan ... Shi-Zhong Luo
    A biochemical approach shows co-phase separation of CCL5 with heparan sulfate establishes a specific chemokine concentration gradient for chemotactic activity.

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