October 2024

Cover articles

    1. Evolutionary Biology
    2. Medicine

    Evolution and infertility

    Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
    1. Evolutionary Biology

    Exploring butterfly extinction

    Toni de-Dios, Claudia Fontsere ... Carles Lalueza-Fox
    1. Evolutionary Biology

    Extinction of the Xerces Blue

    Toni de-Dios, Claudia Fontsere ... Carles Lalueza-Fox
    1. Developmental Biology
    2. Neuroscience

    Ketogenic diet to the rescue

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes

Highlights controls:

Research articles

    1. Developmental Biology
    2. Genetics and Genomics

    Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

    Sharvani Mahadevaraju, Soumitra Pal ... Brian Oliver
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Reproducibility of in vivo electrophysiological measurements in mice

    International Brain Laboratory, Kush Banga ... Ilana B Witten
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

    Chinmaya Jena, Saillesh Chinnaraj ... Nishad Matange
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

    Xinlei Cai, Yi Ye ... Hongbin Ji
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Oviductin sets the species-specificity of the mammalian zona pellucida

    Daniel de la Fuente, Maria Maroto ... Alfonso Gutiérrez-Adán
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses

    Bill Kwan-wai Chan, Yingxue Li ... Sheng Chen
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Comparative neuroimaging of the carnivoran brain: Neocortical sulcal anatomy

    Magdalena Boch, Katrin Karadachka ... Rogier B Mars
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

    Tingting Li, Wenwen Shi ... Yong Q Zhang
    Upon traumatic brain injury in Drosophila adults, a previously unknown Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes.
    1. Cell Biology

    Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

    Ewa K Bomba-Warczak, Karen M Velez ... Francesca E Duncan
    Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hundreds of myosin 10s are pushed to the tips of filopodia and could cause traffic jams on actin

    Julia Shangguan, Ronald S Rock
    Improved technology for counting proteins captures myosin 10 dynamics throughout the filopodial lifecycle, defines requirements for initiating filopodia, and reveals a crowded filopodial tip where motors frequently exceed available actin.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
    Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.
    1. Immunology and Inflammation

    Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

    Javier Ruiz-Navarro, Sara Fernández-Hermira ... Manuel Izquierdo Pastor
    FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.
    1. Plant Biology

    Structural basis for molecular assembly of fucoxanthin chlorophyll a/c-binding proteins in a diatom photosystem I supercomplex

    Koji Kato, Yoshiki Nakajima ... Ryo Nagao
    The molecular mechanisms of FCPI assembly and selective binding are revealed through comparison of PSI-FCPI structures in two diatom species.
    1. Immunology and Inflammation
    2. Neuroscience

    Photoreceptor loss does not recruit neutrophils despite strong microglial activation

    Derek Power, Justin Elstrott, Jesse Schallek
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Neuroscience

    Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signaling pathway

    Mahima Bose, Ishita Talwar ... Shubha Tole
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

    Emily E Oor, Emilio Salinas, Terrence R Stanford
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Esther Park ... Michel Bagnat
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors

    Michel Fallah, Kenea C Udobi ... Rebekah C Evans
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest

    Dhaval A Ghone, Edward L Evans ... Aussie Suzuki
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

    Xingye Wang, Jie Wang ... Beinan Wang
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing crossover formation in C. elegans

    Bhumil Patel, Maryke Grobler ... Needhi Bhalla
    Not revised
    Reviewed Preprint v1
    1. Medicine

    The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

    Pinanong Na-Phatthalung, Shumin Sun ... Fudi Wang
    Zinc transporter Slc30a1 mediates antibacterial defense in macrophages.
    1. Neuroscience

    Transformation of valence signaling in a mouse striatopallidal circuit

    Donghyung Lee, Nathan Lau ... Cory M Root
    The representation of odor transforms from high dimensional, population level encoding of valence and identity in the OT, to a low dimensional representation of valence in the VP.
    1. Immunology and Inflammation
    2. Neuroscience

    Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma

    Sachin P Gadani, Saumitra Singh ... Pavan Bhargava
    Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
    1. Structural Biology and Molecular Biophysics

    Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins

    Sanbo Qin, Huan-Xiang Zhou
    SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.
    1. Neuroscience

    PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

    Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
    In neurons of the Drosophila brain’s memory center, PKCδ relays a post-learning dopamine signal to mitochondria, boosting their metabolic activity and thereby unlocking long-term memory formation.
    1. Cell Biology
    2. Neuroscience

    Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion

    Lu Yang, Zijin Lin ... Li Liu
    The established triple co-culture blood-–brain barrier (BBB) model could be used for predicting drugs’ BBB permeability, and co-culture with neurons and astrocytes enhanced brain endothelial cells’ integrity by secreting GDNF, which upregulated claudin-5 and VE-cadherin expression.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

    Hoang Thanh Hai, Le Thanh Hoang Nhat ... Nguyen Thuy Thuong Thuong
    An unbiased transcriptomic analysis enhances understanding of inflammatory pathways and genes linked to TBM pathogenesis and mortality, identifying potential markers for poor prognosis or therapeutic targets.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Intraspecific predator interference promotes biodiversity in ecosystems

    Ju Kang, Shijie Zhang ... Xin Wang
    Intraspecific predator interference enables a wide range of consumer species to coexist with a limited variety of resources, explaining the paradox of the plankton and species diversity patterns across ecosystems.
    1. Cell Biology
    2. Neuroscience

    Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover

    Seung Mi Kim, Yaw Quagraine ... Jung Hwan Kim
    Coupling between subcellular localization and protein turnover of a neuronal stress kinase, DLK, and its role in neuronal stress responses in Drosophila.
    1. Structural Biology and Molecular Biophysics

    Elucidating ATP’s role as solubilizer of biomolecular aggregate

    Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
    ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    PRR adjuvants restrain high stability peptides presentation on APCs

    Bin Li, Jin Zhang ... Chao Wu
    Adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of APCs, preferring the presentation of low-affinity exogenous peptides rather than high-affinity peptides.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

    Cecilia Tubert, Rodrigo M Paz ... Mario G Murer
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

    Yingjie Sun, Changheng Li ... Youngnam N Jin
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Statistical learning beyond words in human neonates

    Ana Fló, Lucas Benjamin ... Ghislaine Dehaene-Lambertz
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response

    Angelica A Gopal, Bianca Fernandez ... J Matthew Dubach
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation

    HeeYoung Seon, Dongil Chung
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology
    2. Neuroscience

    Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

    Sebastien Bouret, Emmanuel Paradis ... Cecile Garcia
    Across primates, volumes of specific brain regions relate to specific socio-ecological factors, bridging the gap between neuro-cognitive operations from laboratory studies and challenges primates face in their natural environment.
    1. Microbiology and Infectious Disease

    Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

    Matias A Medina, Francisco Fuentes-Villalobos ... Maria Ines Barria
    Longitudinal transcriptomic analysis of unvaccinated patients reveals that early NK cell cytotoxicity activation distinguishes mild from severe COVID-19, supporting the relevance of concerted innate–adaptive immune responses against the virus.
    1. Neuroscience

    Sub-cone visual resolution by active, adaptive sampling in the human foveola

    Jenny L Witten, Veronika Lukyanova, Wolf M Harmening
    High-resolution foveal imaging and micro-psychophysics reveal that the human oculomotor system finely adjusts drift motion of the eye in an acuity task to enhance retinal sampling, achieving sub-cell resolution.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

    Laura Dovek, Krista Marrero ... Vijayalakshmi Santhakumar
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mitochondrial calcium modulates odor-mediated behavioral plasticity in C. elegans

    Hee Kyung Lee, Dong-Kyu Joo ... Kyoung-hye Yoon
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Physics of Living Systems

    Detection of changes in membrane potential by magnetic resonance imaging

    Kyeongseon Min, Sungkwon Chung ... Jang-Yeon Park
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Molecular and Mechanical Signatures Contributing to Epidermal Differentiation and Barrier Formation

    Alexandra Prado-Mantilla, Wenxiu Ning, Terry Lechler
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Social and environmental predictors of gut microbiome age in wild baboons

    Mauna R Dasari, Kimberly E Roche ... Elizabeth A Archie
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Large-scale analysis of the integration of enhancer-enhancer signals by promoters

    Miguel Martinez-Ara, Federico Comoglio, Bas van Steensel
    A high-throughput enhancer-enhancer-promoter reporter assay indicates that pairs of enhancers generally activate promoters in a near-additive manner, and that promoters transform their collective effect non-linearly.
    1. Neuroscience

    Regional response to light illuminance across the human hypothalamus

    Islay Campbell, Roya Sharifpour ... Gilles Vandewalle
    Distinct local dynamics of different hypothalamus areas were detected in response to changing illuminance and could contribute to light’s impact on cognition.
    1. Cancer Biology

    The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization

    Thi Mong Quynh Pham, Thanh Nhan Nguyen ... Le Son Tran
    The integration of pHLA binding and pHLA-TCR analysis effectively improves the precision of insilico neoantigen prioritization, potentially enhancing personalized immunotherapies for colorectal cancer.
    1. Immunology and Inflammation

    Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

    Valentina Stolz, Rafael de Freitas e Silva ... Wilfried Ellmeier
    The transcriptional adapter protein NCOR1 that links chromatin-modifying enzymes with gene-specific transcription factors controls naive and effector regulatory T cell states.
    1. Neuroscience

    Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors

    Olivia C Meisner, Weikang Shi ... Steve WC Chang
    The Marmoset Apparatus for Automated Pulling provides a powerful and scalable experimental platform for studying behavioral and neural mechanisms underlying cooperation in freely moving marmosets.
    1. Biochemistry and Chemical Biology

    A synthetic method to assay polycystin channel biophysics

    Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen
    Synthetic polycystin proteins self-assemble as function channels when reconstituted in lipid vesicles.
    1. Physics of Living Systems

    Information gain at the onset of habituation to repeated stimuli

    Giorgio Nicoletti, Matteo Bruzzone ... Daniel Maria Busiello
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

    Yaroslav I Molkov, Anke Borgmann ... Jeffrey C Smith
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The dominance of global phase dynamics in human cortex, from delta to gamma

    David M Alexander, Laura Dugué
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

    My Tran, Angel J Hernandez Viera ... Charlie Y Mo
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health

    Dianyuan Zhao, Ziwei Huang ... Li Tang
    Hepatic stellate cells play a central role in maintaining liver health by mediating cell-to-cell crosstalk via the production of GDF2 and BMP10.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Emergence of planar cell polarity from the interplay of local interactions and global gradients

    Divyoj Singh, Sriram Ramaswamy ... Mohd Suhail Rizvi
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure

    Paul G Kremer, Elizabeth A Lampros ... Adam W Barb
    Multiple lines of evidence demonstrate that a single N-glycan on one receptor influences the strength of a cytotoxic response elicited by natural killer cells following stimulation with an antibody-coated target.
    1. Cell Biology
    2. Neuroscience

    A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

    Jun Sun, Francisca Rojo-Cortés ... Alicia Hidalgo
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Increasing adult-born neurons protects mice from epilepsy

    Swati Jain, John J LaFrancois ... Helen E Scharfman
    Increasing adult-born neurons in the dentate gyrus reduces neuronal loss and chronic seizures in female mice using a mouse model of temporal lobe epilepsy.
    1. Genetics and Genomics

    Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle

    Daigo Miyazaki, Mitsuto Sato ... Akinori Nakamura
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Cell Biology

    Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

    Seiichi Koike, Masashi Tachikawa ... Masayuki Masu
    There are two distinct modes of late endosome fusion in the mouse yolk sac visceral endoderm cells and actin dynamics plays a role in regulating vesicle fusion.
    1. Neuroscience

    Characterization of Postsynaptic Glutamate Transporter Functionality in the Zebrafish Retinal First Synapse Across Different Wavelengths

    Marco Garbelli, Stephanie Niklaus, Stephan CF Neuhauss
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Membrane potential modulates ERK activity and cell proliferation

    Mari Sasaki, Masanobu Nakahara ... Fumihito Ono
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language

    Zhuoqiao Hong, Haocheng Wang ... Ariel Goldstein
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

    Xiayu Chen, Xingyu Liu ... Jesse Gomez
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy

    Jing Lu, Hao Xu ... Kai Lei
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Valence and Salience Encoding in the Central Amygdala

    Mi-Seon Kong, Ethan Ancell ... Larry S Zweifel
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Medicine

    LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

    Xianghong Xie, Mingyue Gao ... Xiaojun Liu
    LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity

    Pinhua Wang, Sunayana Sarkar ... Man Mohan
    DYRK1A, a kinase associated with intellectual developmental disorders and organ growth regulation, functions in cell growth by promoting mTORC1 activity.
    1. Cancer Biology

    Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

    Einav Someach, Debdatta Halder ... Itay Tirosh
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

    Tisa Frelih, Andraž Matkovič ... Grega Repovš
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions

    Andrea Sattin, Chiara Nardin ... Tommaso Fellin
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

    Jo-Chiao Wang, Theo Crosson ... Sebastien Talbot
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression

    Nuclear Argonaute protein NRDE-3 switches small RNA binding partners during embryogenesis coincident with the formation of SIMR granules

    Shihui Chen, Carolyn M Phillips
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Prolonged Pain Reliably Slows Peak Alpha Frequency by Reducing Fast Alpha Power

    Andrew J Furman, Mariya Prokhorenko ... David A Seminowicz
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    AIVE: accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis

    Jongkeun Park, Won Jong Choi ... Dongwan Hong
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Identification of the trail-following pheromone receptor in termites

    Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Genetics and Genomics

    DGRPool, a web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits

    Vincent Gardeux, Roel PJ Bevers ... Bart Deplancke
    The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Neuroscience

    Working memory gating in obesity is moderated by striatal dopaminergic gene variants

    Nadine Herzog, Hendrik Hartmann ... Annette Horstmann
    Genetic analyses suggest that advantageous genotypes can mitigate the negative effects of high body mass index on cognitive functions involving information updating.
    1. Ecology

    Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

    Astrid Katharina Maria Stubbusch, Johannes M Keegstra ... Glen G D'Souza
    Degradation products of polysaccharides trigger partial population dispersal and alter cellular metabolism, shaping the marine biomass decomposition by foraging bacteria.
    1. Cell Biology

    Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

    Georgia Maria Sagia, Xenia Georgiou ... Sofia Dimou
    Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.
    1. Cell Biology

    Secreted exosomes induce filopodia formation

    Caitlin McAtee, Mikin Patel ... Alissa M Weaver
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression

    Shengze Yao, Yesu Jeon ... Jeannie T Lee
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Balancing safety and efficiency in human decision making

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    The flexible stalk domain of sTREM2 modulates its interactions with phospholipids in the brain

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments

    Jordan Breffle, Hannah Germaine ... Paul Miller
    Computational simulations and data analysis show that random clustering in the connections of neurons receiving minimal external cues can generate place fields and their spontaneous activation in trajectory-like sequences.
    1. Developmental Biology
    2. Neuroscience

    The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
    PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Trans regulation of an odorant binding protein by a proto-Y chromosome affects male courtship in house fly

    Pablo J Delclos, Kiran Adhikari ... Richard Meisel
    An integrative approach is used to identify a mechanism by which the fitness effects of Y chromosomes can manifest via trans effects on autosomal genes, through their effects on male courtship and other sexually selected traits.
    1. Cancer Biology

    Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

    Tristan Gicquel, Fabio Marchiano ... Alice Carrier
    Pancreatic cancer-associated muscle atrophy is characterized by strong mitochondrial metabolic defects that are not limited to carbohydrate, protein, and redox metabolism, but also concern lipid and nucleic acid metabolisms.
    1. Neuroscience

    Direct observation of the neural computations underlying a single decision

    Natalie Steinemann, Gabriel M Stine ... Michael N Shadlen
    Simultaneous recording from many neurons in macaque lateral intraparietal area reveals the elusive drift-diffusion signal, long suspected to underlie individual perceptual decisions and response times.
    1. Genetics and Genomics
    2. Neuroscience

    Population clustering of structural brain aging and its association with brain development

    Haojing Duan, Runye Shi ... Jianfeng Feng
    Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.
    1. Cell Biology

    Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

    Revathi Balasubramanian, Krishnakumar Kizhatil ... Simon WM John
    A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.
    1. Neuroscience

    A neurotransmitter atlas of C. elegans males and hermaphrodites

    Chen Wang, Berta Vidal ... Oliver Hobert
    Expression pattern analysis of neurotransmitter synthesis, secretion, and reuptake machinery reveals animal-wide usage of neurotransmitters in both sexes of Caenorhabditis elegans.
    1. Neuroscience

    Characterization of direct Purkinje cell outputs to the brainstem

    Christopher H Chen, Zhiyi Yao ... Wade G Regehr
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Expression of most retrotransposons in human blood correlates with biological aging

    Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
    Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Extreme positive epistasis for fitness in monosomic yeast strains

    Hanna Tutaj, Katarzyna Tomala ... Ryszard Korona
    Monosomy in yeast results in numerous gene dosage insufficiencies with potentially lethal collective effect, but strong positive epistasis rooted in the modular structure of cell metabolism cancels it.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants

    Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
    Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.
    1. Cell Biology
    2. Cancer Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Range geographies, not functional traits, explain convergent range and phenology shifts under climate change

    Catherine Sirois-Delisle, Susan CC Gordon, Jeremy T Kerr
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Neuroscience

    Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs

    Matthieu K Chardon, Y Curtis Wang ... Charles J Heckman
    Estimating the organization of supraspinal input to motoneurons in humans is not currently possible, but a promising reverse engineering technique has been developed using large-scale supercomputing and computational neuroscience.
    1. Neuroscience

    Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice

    Quynh Anh Thi Nguyen, Andrea Rocha ... Sachiko Haga-Yamanaka
    A molecular genetics study reveals an accessory olfactory-to-hypothalamic circuit in mice that optimizes defensive behaviors according to the imminence of predator threats.
    1. Neuroscience

    PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles

    Lu Li, Yin Li ... Fadao Tai
    Activation of oxytocin (OT) neurons in the paraventricular nucleus or their projections to medial prefrontal cortex or periphery OT administration facilitated pup caring and inhibited infanticide, while inhibitions of these neurons and projections promoted infanticide.
    1. Cell Biology

    Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

    Li Sun, Xuejin Chen ... Quan-wen Jin
    Inhibitory effect on the activation of anaphase-promoting complex/cyclosome (APC/C) by MAPK Pmk1.
    1. Neuroscience

    Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

    Adlin Abramian, Rein I Hoogstraaten ... Matthijs Verhage
    Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
    1. Microbiology and Infectious Disease

    A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin

    Maneesh Kumar Singh, Victoria Ann Bonnell ... Celia RS Garcia
    Multi-omic analyses reveal that the chromatin-associated microrchidia protein, MORC (PF3D7_1468100), at the blood stage of the human malaria parasite, Plasmodium falciparum, interacts with a range of nuclear proteins.
    1. Microbiology and Infectious Disease

    Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    MeiQing Han, Xia Wang ... Fan Yang
    Gut microbiota dysbiosis increased Nos2 expression through the 'gut–lung axis', and altered intracellular antimicrobial and anti-inflammatory environment by abnormal NO, ROS, and Defb1, thereby promoting Mycobacteria colonization in mouse lungs.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    HIV integrase compacts viral DNA into biphasic condensates

    Pauline J Kolbeck, Marjolein de Jager ... Willem Vanderlinden
    Not revised
    Reviewed Preprint v1
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene

    Vendula Šlechtová, Tomáš Dvořák ... Jörg Bohlen
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

    Kai Xu, Xiaoyue Pan ... Guoying Yu
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Reprograming gene expression in hibernating C. elegans involves the IRE-1/XBP-1 pathway

    Melanie L Engelfriet, Yanwu Guo ... Rafal Ciosk
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System

    Zeng-Hang Wang, Ying An ... Tao Dong
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum

    Lin Wei, Hai-Yan Cao ... Fuchuan Li
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Protein-Induced Membrane Strain Drives Supercomplex Formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Cancer Biology

    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    Chong Zhang, Zuoyan Zhang ... Yangling Li
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Discovering Root Causal Genes with High Throughput Perturbations

    Eric V Strobl, Eric Gamazon
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Cancer Biology

    Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    Lucian DiPeso, Sriram Pendyala ... Emily M Hatch
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

    Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology

    Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
    Recovery of proteins from aggregates by Hsp70 is boosted by the Hsp110 co-chaperone, which promotes abundant Hsp70 recruitment to aggregates and supports initial aggregate remodelling into small assemblies.
    1. Ecology

    Contrasting responses to aridity by different-sized decomposers cause similar decomposition rates across a precipitation gradient

    Viraj R Torsekar, Nevo Sagi ... Dror Hawlena
    Contrasting climatic dependencies of macrofauna and microorganisms generate similar whole-community decomposition rates across a precipitation gradient, plausibly resolving the longstanding puzzle of why arid-land litter decomposition is decoupled from precipitation.
    1. Neuroscience

    Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis

    Kyra Schapiro, JD Rittenberg ... Eve Marder
    The hyperpolarization-activated inward current plays an important role in regulating both smooth transitory responses and persistent increases in pyloric frequency during temperature fluctuations in Cancer borealis.
    1. Cancer Biology

    A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice

    Zheng Liu
    The new cancer treatment strategy reduces the volume of mouse cutaneous squamous cell carcinoma and reverses the expression of tumor marker proteins by stimulating the production of serum-based antibodies.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Light-driven synchronization of optogenetic clocks

    Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
    Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.
    1. Chromosomes and Gene Expression

    The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2

    Shamayita Roy, Hemanta Adhikary ... Damien D'Amours
    1. Chromosomes and Gene Expression

    Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

    Linda S Rubio, Suman Mohajan, David S Gross
    In response to ethanol stress, the yeast transcription factor Hsf1 forms nuclear condensates and drives the coalescence of target genes prior to their transcriptional activation while in response to thermal stress these three phenomena are tightly coordinated.
    1. Immunology and Inflammation

    Mast cells promote pathology and susceptibility in tuberculosis

    Ananya Gupta, Vibha Taneja ... Shabaana A Khader
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Group identification drives brain integration for collective performance

    Enhui Xie, Shuyi Zha ... Xianchun Li
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A novel method (RIM-Deep) enhances imaging depth and resolution stability of deep-cleared brain tissue in inverted confocal microscopy

    Yisi Liu, Pu Wang ... Hongwei Zhou
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cholecystokinin modulates age-dependent Thalamocortical Neuroplasticity

    Xiao Li, Jingyu Feng ... Jufang He
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Maternal behavior influences vocal practice and learning processes in the greater sac-winged bat

    Ahana A Fernandez, Nora Serve ... Mirjam Knörnschild
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Self-association enhances early attentional selection through automatic prioritization of socially salient signals

    Meike Scheller, Jan Tünnermann ... Jie Sui
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

    Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide

    Zhiyan Wang, Nore Ojogun ... Mingfang Lu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking

    Juliane Schubert, Quirin Gehmacher ... Nathan Weisz
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Permissive and instructive Hox codes govern limb positioning

    Yajun Wang, Maik Hintze ... Ruijin Huang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

    María Pedraza, Valentina Grampa ... Justine Masson
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Robust optogenetic inhibition with red-light-sensitive anion-conducting channelrhodopsins

    Johannes Oppermann, Andrey Rozenberg ... Peter Hegemann
    Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.
    1. Neuroscience

    Multi-level processing of emotions in life motion signals revealed through pupil responses

    Tian Yuan, Li Wang, Yi Jiang
    Intact and local emotional biological motion exerted distinct influences on pupil responses, wherein the emotional modulation observed in intact biological motion is linked to individual autistic traits.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

    Archana Kamalakar, Brendan Tobin ... Steven L Goudy
    Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
    1. Neuroscience

    Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback

    Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon
    Spinal circuits performing speed- and context-dependent control of locomotion in mammals can operate in different regimes with prevailing role of central mechanisms, supraspinal signals, or sensory feedback.
    1. Computational and Systems Biology

    Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

    Krutik Patel, Matt Barter ... Daryl P Shanley
    A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.
    1. Chromosomes and Gene Expression

    A comparative study of the cryo-EM structures of Saccharomyces cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

    Ester Vazquez-Fernandez, Jing Yang ... David Barford
    The yeast APC/C cryo-EM structure reveals substantial similarities with the human APC/C structure but also important differences in mechanisms of phosphorylation-dependent regulation and activation by coactivators.
    1. Structural Biology and Molecular Biophysics

    TRPML1 gating modulation by allosteric mutations and lipids

    Ninghai Gan, Yan Han ... Youxing Jiang
    Design and characterization of allosteric mutations that recapitulate TRPML1 gating and structural insights into PI(4,5)P2 and sphingomyelin inhibition of TRPML1.
    1. Developmental Biology
    2. Plant Biology

    Root-specific theanine metabolism and regulation at the single-cell level in tea plants (Camellia sinensis)

    Shijia Lin, Yiwen Zhang ... Zhaoliang Zhang
    A single-cell RNA sequencing reveals cell heterogeneity of secondary metabolism in tea plant root and a proposed model in which the theanine biosynthesis pathway occurs via multicellular compartmentation.
    1. Immunology and Inflammation

    Heat Shock Factor Regulation of Antimicrobial Peptides Expression Suggests a Conserved Defense Mechanism Induced by Febrile Temperature in Arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Ribosome demand links transcriptional bursts to protein expression noise

    Sampriti Pal, Upasana Ray, Riddhiman Dhar
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles

    Lizi Zhang, Yishan Qu ... Fadao Tai
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure

    Tao He, Xizi Gong ... Fang Fang
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos

    Yanlin Hou, Zhengwen Nie ... Hans R Schöler
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

    Maiko Kawasaki, Katsushige Kawasaki ... Atsushi Ohazama
    Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
    1. Chromosomes and Gene Expression

    Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

    Zulong Chen, Xin Wang ... Jessica K Tyler
    Genetic, cellular, and molecular analyses reveal that the reduced abundance of total nascent transcripts that occurs after irradiation is largely due to the repression of histone and rRNA encoding genes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

    Tianyu Zhao, Hui Li ... Li Chen
    A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons

    Amy N Shore, Keyong Li ... Matthew C Weston
    An epilepsy-associated potassium channel variant causes neuron-type-dependent alterations in ionic currents, neuronal excitability, and network connectivity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Regulatory genome annotation of 33 insect species

    Hasiba Asma, Ellen Tieke ... Marc S Halfon
    Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide mapping of native co-localized G4s and R-loops in living cells

    Ting Liu, Xing Shen ... Zhihong Xue
    The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
    1. Neuroscience

    Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices

    Yanqi Liu, Pol Bech ... Carl CH Petersen
    Whole-brain light-sheet imaging of axons segmented by trained convolutional networks reveals distinct projection patterns of genetically defined classes of neurons in primary and secondary whisker-related somatosensory cortices.
    1. Neuroscience

    Morphology and synapse topography optimize linear encoding of synapse numbers in Drosophila looming responsive descending neurons

    Anthony Moreno-Sanchez, Alexander N Vasserman ... Jessica Ausborn
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Quantification of Salmonella enterica serovar Typhimurium Population Dynamics in Murine Infection Using a Highly Diverse Barcoded Library

    Julia A Hotinger, Ian W Campbell ... Matthew K Waldor
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

    Yan Qian, Qiannv Liu ... Pengyan Xia
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

    Po-Kai Wang, Keng-Hui Lin, Tang K Tang
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Avian-restrict Salmonella transition to endemicity is accompanied by localized resistome adaptation

    Chenghao Jia, Chenghu Huang ... Min Yue
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Cell Biology

    Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

    Alexandra Urbancokova, Terezie Hornofova ... Pavla Vasicova
    Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.
    1. Evolutionary Biology
    2. Medicine

    The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
    An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.
    1. Neuroscience

    Sensory-memory interactions via modular structure explain errors in visual working memory

    Jun Yang, Hanqi Zhang, Sukbin Lim
    Two-module networks, combining sensory efficient coding and attractor dynamics for memory maintenance, effectively explain working memory error patterns, highlighting the role of sensory-memory interactions in continuously shaping memory representations.
    1. Developmental Biology
    2. Genetics and Genomics

    Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

    Morgane Djebar, Isabelle Anselme ... Christine Vesque
    Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Benchmarking reveals superiority of deep learning variant callers on bacterial nanopore sequence data

    Michael B Hall, Ryan R Wick ... Lachlan Coin
    Nanopore sequencing effectively resolves key challenges in bacterial small variant detection, providing a more accurate alternative to traditional sequencing methods.
    1. Immunology and Inflammation

    Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

    Chenchen Mao, Yanyu Chen ... Xiangyang Xue
    Resting natural killer cells promote the progress of colon cancer liver metastasis (CCLM), which may be exploited for novel strategies to improve therapeutic outcomes for patients with CCLM.
    1. Computational and Systems Biology
    2. Cancer Biology

    Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

    Erika Tsingos, Advaita M Dick, Baubak Bajoghli
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neural mechanisms of credit assignment for delayed outcomes during contingent learning

    Phillip P Witkowski, Lindsay Rondot ... Erie D Boorman
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin mediated endocytosis

    Surya Bansi Singh, Shatruhan Singh Rajput ... Deepa Subramanyam
    1. Cancer Biology
    2. Computational and Systems Biology

    Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq data

    Aurélie Anne-Gaëlle Gabriel, Julien Racle ... David Gfeller
    EPIC-ATAC accurately quantifies cell-type heterogeneity in tumor bulk ATAC-Seq samples using reliable cell-type specific chromatin accessibility markers for the major cell types found in tumor microenvironments.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish

    Laura Massoz, David Bergemann ... Isabelle Manfroid
    Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.
    1. Immunology and Inflammation
    2. Neuroscience

    Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion

    Yuedan Wang, Ying Li ... Xuan Xiao
    The UPOAO model effectively replicates retinal ischemia in retinal artery occlusion, providing a novel platform for identifying pathogenic genes and advancing therapeutic research.
    1. Neuroscience

    Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping

    Yafen Li, Yixuan Lin ... Antao Chen
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Hierarchical cortical plasticity in congenital sight impairment

    Roni O Maimon-Mor, Mahtab Farahbakhsh ... Tessa M Dekker
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Tripartite organization of brain state dynamics underlying spoken narrative comprehension

    Liu Lanfang, Jiang Jiahao ... Guosheng Ding
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

    Matthew B McDougal, Anthony M De Maria ... John W Schoggins
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses

    Magdalena Ziółkowska, Narges Sotoudeh ... Kasia Radwanska
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Low-dimensional olfactory signatures of fruit ripening and fermentation

    Yuansheng Zhou, Thomas F O’Connell ... Tatyana O Sharpee
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG

    Cristina Gil Avila, Elisabeth S May ... Markus Ploner
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    PD-1 negatively regulates helper T cell differentiation into Th2

    Masaki Tajima, Naoko Ikuta ... Akio Ohta
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    New soft tissue data of pterosaur tail vane reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins

    Natalia Jagielska, Thomas G Kaye ... Michael Pittman
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Physics of Living Systems

    Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans

    Iksoo Chang, Taegon Chung, Sangyeol Kim
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Epidemiology and Global Health

    Menopausal hormone therapy and the female brain: leveraging neuroimaging and prescription registry data from the UK Biobank cohort

    Claudia Barth, Liisa AM Galea ... Ann-Marie G de Lange
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Immunology and Inflammation

    A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

    Akashdip Singh, Alberto Miranda Bedate ... Linde Meyaard
    A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.
    1. Evolutionary Biology

    Alasemenia, the earliest ovule with three wings and without cupule

    Deming Wang, Jiangnan Yang ... Pu Huang
    Early seeds without cupules evolved functions in wind dispersal and probable photosynthetic nutrition and three-winged seeds are more adapted to wind dispersal than seeds with one, two, or four wings.
    1. Microbiology and Infectious Disease

    A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides

    Malik Zohaib Ali, Taru S Dutt ... Mercedes Gonzalez Juarrero
    A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides without showing linezolid associated adverse effects.
    1. Biochemistry and Chemical Biology

    DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

    Emily L Dearlove, Chatrin Chatrin ... Danny T Huang
    Biochemical and structural analyses reveal direct ubiquitin modification of single-stranded nucleic acids, catalysed by the DTX3L ubiquitin ligase.
    1. Immunology and Inflammation

    LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization

    Hyun-Chae Lee, Sun-Hee Park ... Kyoung Seob Song
    PEGylated PDZ peptide reduces LPS-induced systemic inflammation, restores tissue integrity, decreases pro-inflammatory cytokines, and modulates macrophage populations, showing potential as a therapeutic for systemic inflammation.
    1. Genetics and Genomics

    Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

    Sophie Debaenst, Tamara Jarayseh ... Andy Willaert
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Evolution of novel mimicry polymorphisms through Haldane’s sieve and rare recombination

    Riddhi Deshmukh, Saurav Baral ... Krushnamegh Kunte
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René A Frank
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Ventral Morphology and Ecological Implications of Cindarella eucalla (Artiopoda, Xandarellida) from Chengjiang Biota, China

    Maoyin Zhang, Yu Liu ... Xianguang Hou
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Desmodium Volatiles in “Push-Pull” Agriculture and Protection Against the Fall Armyworm, Spodoptera frugiperda

    Daria M Odermatt, Frank Chidawanyika ... Meredith C Schuman
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Olfactory basis for essential amino acid perception during foraging in Caenorhabditis elegans

    Ritika Siddiqui, Nikita Mehta ... Varsha Singh
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

    Qi Zeng, Chen Yao ... Shuai Chen
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    Yuji Miyatake, Tomokatsu Ikawa ... Ai Kotani
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

    Nicole Foxworth, Julie Wells ... Maria Loscertales
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen

    Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Outer hair cells stir cochlear fluids

    Choongheon Lee, Mohammad Shokrian ... Jong-Hoon Nam
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology

    Single turnover transient state kinetics reveals processive protein unfolding catalyzed by Escherichia coli ClpB

    Jaskamaljot Kaur Banwait, Liana Islam, Aaron L Lucius
    Development of sequential mixing, single turnover stopped-flow approach reveals processive protein unfolding catalyzed by Escherichia coli ClpB.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic basis of lipopolysaccharide export by LptB2FGC

    Marina Dajka, Tobias Rath ... Benesh Joseph
    LptC regulates the LPS entry gate in LptB2FG, likely through a dynamic behavior of its transmembrane helix, while the β-jellyroll domains are tethered in the periplasm.
    1. Computational and Systems Biology
    2. Neuroscience

    Robust, fast and accurate mapping of diffusional mean kurtosis

    Megan E Farquhar, Qianqian Yang, Viktor Vegh
    Mean kurtosis brain maps, derived from a sub-diffusion model with a novel clinically feasible two-diffusion-time acquisition, exhibit superior tissue contrast compared to the traditional diffusional kurtosis imaging (DKI).
    1. Microbiology and Infectious Disease

    Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

    Nicholas J Hathaway, Isaac E Kim ... Jeffrey A Bailey
    Sequence analyses show a pfhrp3 deletion mechanism involves duplication of chromosome 11 segment, which is normally removed via negative selection, and specific conditions are needed for spread including low transmission.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

    Yan Chen, Ruizhi Yang ... Zhao Shan
    Chi3l1 binds to bacterial peptidoglycan, helping anchor and organize bacteria within the mucus layer.
    1. Structural Biology and Molecular Biophysics

    Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

    Shristi Pawnikar, Brenda S Magenheimer ... Yinglong Miao
    Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.
    1. Cancer Biology

    Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

    Xujin Wei, Jie Liu ... Huiqin Zhuo
    CUT-Tag is used to identify super-enhancers (SEs) for the first time in gastric cancer, and the mRNA decay mechanism activated by SE-driven ZFP36L1 in infiltrative gastric cancer along with innovative experimental evidence demonstrating SPI1/ZFP36L1/HDAC3/PD-L1 signaling axis are presented.
    1. Cancer Biology

    BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

    Paul Huchede, Swann Meyer ... Marie Castets
    BMP2 and 7 synergize with H3.3K27M epigenetic context to establish a quiescent but invasive state in pediatric diffuse midline gliomas.
    1. Immunology and Inflammation

    Gasdermin D-Mediated Neutrophil Pyroptosis drives Inflammation in Psoriasis

    Jian Liu, YuYing Jiang ... ZhiQiang Yin
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

    Joseph Hanna, Yacine Touahri ... Carol Schuurmans
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    Guylaine Hoffner, Pablo Castro ... Bechir Jarraya
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    The Origin of Movement Biases During Reaching

    Tianhe Wang, Ryan J Morehead ... Richard B Ivry
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Sensitivity to visual features in inattentional blindness

    Makaela Nartker, Chaz Firestone ... Ian Phillips
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Automatic learning mechanisms for flexible human locomotion

    Cristina Rossi, Kristan A Leech ... Amy J Bastian
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species

    Toni de-Dios, Claudia Fontsere ... Carles Lalueza-Fox
    The retrieval of whole genomes from museum specimens from the extinct Xerxes Blue butterfly shows signals of population decline that could be use to identify present-day endangered insect species.
    1. Epidemiology and Global Health

    Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

    Xiaoning Wang, Jinxiang Zhao ... Dong Liu
    Live imaging and single-cell sequencing analyses on zebrafish models revealed that noncaloric monosaccharides and glucose similarly induce excessive blood vessel formation due to endothelial cells' increased formation of tip cells.
    1. Microbiology and Infectious Disease

    Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms

    Hebin Liao, Xiaodan Yan ... Yingying Pu
    c-di-GMP and HipH function as a toxin-antitoxin-like module to regulate persister cell formation in bacterial biofilms.
    1. Developmental Biology

    A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

    Ming-Ming Chen, Yue Zhao ... Zheng-Xing Lian
    Newly prepared double gene-edited sheep provide excellent models for skeletal muscle growth and development, and muscle diseases such as muscle atrophy and sarcopenia.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

    Jianwen Chen, Bao Zhao ... Haitao Wen
    Deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models.
    1. Neuroscience

    A chromatic feature detector in the retina signals visual context changes

    Larissa Höfling, Klaudia P Szatko ... Thomas Euler
    A modelling-based analysis reveals a novel type of selectivity for chromatic contrast in a mouse retinal ganglion cell type, and experimental evidence shows that this feature makes this cell type well suited for detecting behaviourally relevant changes in visual context.
    1. Developmental Biology

    The role of Imp and Syp RNA-binding proteins in precise neuronal elimination by apoptosis through the regulation of transcription factors

    Wenyue Guan, Ziyan Nie ... Jonathan Enriquez
    Genetic manipulations reveal how the spatiotemporal expression pattern of two RNA-binding proteins regulates the eventual number of motoneurons in a Drosophila neuronal lineage.
    1. Neuroscience

    Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    A unique cell division protein critical for the assembly of the bacterial divisome

    Xiao Chu, Lidong Wang ... Zhaoqing Luo
    Identifying gain-of-function division variants that suppress the elongated cell division defect phenotype caused by Aeg1 depletion.
    1. Microbiology and Infectious Disease

    Peptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in Escherichia coli

    Yucheng Liang, Jean-Emmanuel Hugonnet ... Michel Arthur
    The Braun lipoprotein is tethered to peptidoglycan independently from the insertion of newly-synthesized peptidoglycan subunits into the expanding cell wall generating a dynamic equilibrium between free and bound protein forms.
    1. Genetics and Genomics

    Novel risk loci for COVID-19 hospitalization among admixed American populations

    Silvia Diz-de Almeida, Raquel Cruz ... Ángel Carracedo
    Genetic association analyses in Latin American individuals revealed two additional loci associated with COVID-19 that were not previously found in other population groups.
    1. Genetics and Genomics

    An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis

    Jake D Lehle, Yu-Huey Lin ... John R McCarrey
    The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
    1. Medicine

    Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

    Paul Horn, Jenny Norlin ... Philip N Newsome
    Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.
    1. Neuroscience

    Recording γ-secretase activity in living mouse brains

    Steven S Hou, Yuya Ikegawa ... Masato Maesako
    A new imaging tool to record γ-secretase activity in vivo.
    1. Plant Biology

    Pectin methylesterase activity is required for RALF1 peptide signalling output

    Ann-Kathrin Rößling, Kai Dünser ... Jürgen Kleine-Vehn
    The methylation status of pectin acts as a critical signalling scaffold for RALF peptides, linking extracellular matrix dynamics to peptide hormone-mediated regulation of plant root growth.
    1. Neuroscience

    The value of initiating a pursuit in temporal decision-making

    Elissa Sutlief, Charlie Walters ... Marshall G Hussain Shuler
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

    Zhengming Tian, Feiyang Jin ... Jia Liu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury

    Renaud Prével, Erwan Pernet ... Maziar Divangahi
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

    Hans Kirschner, Hanna M Molla ... Markus Ullsperger
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    AgRP1 modulates breeding season-dependent feeding behavior in female medaka

    Yurika Tagui, Shingo Takeda ... Chie Umatani
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The replication principle revisited: a shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    Gianpaolo Antonio Basile, Augusto Ielo ... Alberto Cacciola
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Human Brain Barcodes

    Darryl Shibata
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

    Bhanu Shrestha, Jiun Sang ... Youngseok Lee
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Cardiac afferent signals can facilitate visual dominance in binocular rivalry

    John P Veillette, Fan Gao, Howard C Nusbaum
    Sensations arising from internal organs like the heart can affect how the brain decides between two mutually incompatible perceptions of the same visual stimulus.
    1. Chromosomes and Gene Expression

    The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay

    Moran Kelbert, Antonio Jordán-Pla ... Mordechai Choder
    Class-specific transcription factor links transcription backtracking with cytoplasmic mRNA decay via co-transcriptional interaction with nascent transcripts.
    1. Chromosomes and Gene Expression

    An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

    Chileleko Siachisumo, Sara Luzzi ... David J Elliott
    A family of RNA binding proteins that diverged 200 million years ago have parallel roles in protecting the transcriptomic integrity of ultra-long exons within their respective cell types.
    1. Neuroscience

    I-Spin live, an open-source software based on blind-source separation for real-time decoding of motor unit activity in humans

    Julien Rossato, François Hug ... Simon Avrillon
    I-Spin enables researchers to decode motor unit firings from surface and intramuscular electromyographic signals in real time.
    1. Evolutionary Biology

    Multiple origins of dorsal ecdysial sutures in trilobites and their relatives

    Kun-sheng Du, Jin Guo ... Ai-lin Chen
    New morphological information on the Cambrian artiopodan Acanthomeridion, including CT data, demonstrate that dorsal ecdysial sutures likely evolved multiple times within this group.
    1. Cell Biology
    2. Developmental Biology

    Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein

    Evgenia Leikina, Jarred M Whitlock ... Leonid Chernomordik
    Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

    Maruti Nandan Rai, Qing Lan ... Koon Ho Wong
    The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

    Joseph A Bisson, Miriam Gordillo ... Todd Evans
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

    Jiayin Gao, Jiawei Wang ... Keliang Wu
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish

    Wenqing Li, Sara McCurdy ... Ho-sup Lee
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos

    Ryan M Finnerty, Daniel J Carulli ... Wipawee Winuthayanon
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

    Shuyu Olivia Zhou, Jonathan P Day ... Francis M Jiggins
    Not revised
    Reviewed Preprint v1
    1. Stem Cells and Regenerative Medicine

    Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

    Jacob W Klemm, Chloe Van Hazel, Robin E Harris
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

    Yutaro Hama, Yuko Fujioka ... Nobuo N Noda
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    A new class of receptors: Lipids regulate mammalian Gsα-stimulated adenylyl cyclase activities via their membrane anchors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

    Bhanu Priya Somashekar, Upinder Singh Bhalla
    Revised
    Reviewed Preprint v2
    1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Prebiotic gas flow environment enables isothermal nucleic acid replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

    Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
    A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.
    1. Neuroscience

    GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex

    Yuan Gao, Yong-Chun Cai ... Xue Mei Song
    Information exchange between the sensory cortex (hMT+) and cognition core (BA46), coupled with hMT+ GABA levels, predicts performance in 3D visuo-spatial ability.
    1. Microbiology and Infectious Disease

    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall

    Carlos A Ramirez Carbo, Olalekan G Faromiki, Beiyan Nan
    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall and thus transmits proton motive force from the inner membrane to cell surface.

Magazine

    1. Stem Cells and Regenerative Medicine

    Notch Signaling: Antibodies get under the skin

    Chiara Levra Levron, Gabriele Piacenti, Giacomo Donati
    1. Stem Cells and Regenerative Medicine

    Immune Cells: Growing microglia in the lab

    Jonathan M Levenson, Hio Tong Kam, Dong Feng Chen
    1. Ecology
    2. Evolutionary Biology

    Camouflage: Tiny particles help insects evade predators

    Lin Wang, Tak-Sing Wong
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cells: Don’t be so naïve

    Valerie Horsley, Aya Nassereddine

  5. Being Neurodivergent in Academia: Navigating neurodiversity in higher education in India

    Deepali Taneja, Poornima Viswanathan, Sahana V Rajan
    1. Neuroscience

    Decisions: Tracking the evolution of a single choice

    Bharath Chandra Talluri, Hendrikje Nienborg
    1. Developmental Biology
    2. Neuroscience

    Brain Development: Investigating the impact of ketogenic diets

    Nalia Samba, Marie Gendrel
    1. Neuroscience

    Vole Parenting: A fine line between attack and care

    Nicole Rigney
    1. Computational and Systems Biology

    Point of View: Being a PhD student in Morocco today

    Anas Bedraoui
    1. Cancer Biology
    2. Genetics and Genomics

    Gene Fusion: Decoding the identity of rare tumors

    Qingchen Yuan, Prabhjot Kaur, Olga A Guryanova
    1. Neuroscience

    Dopamine: Making memories

    Francesco Longo
    1. Neuroscience

    Neuroscience: Unveiling hidden sources of noise

    Morgan Fitzgerald, Eena Kosik, Bradley Voytek