September 2024

Cover articles

    1. Neuroscience

    Memory and mental imagery

    Merlin Monzel, Pitshaporn Leelaarporn ... Cornelia McCormick
    1. Physics of Living Systems

    Meta-Research

    Alex James, Franca Buelow ... Ann Brower
    1. Cell Biology
    2. Developmental Biology

    Growth mechanisms in bone

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    1. Ecology

    Pigeons versus predators

    Mathilde Delacoux, Fumihiro Kano

Highlights controls:

Research articles

    1. Ecology

    Full factorial construction of synthetic microbial communities

    Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Odors drive feeding through gustatory receptor neurons in Drosophila

    Hong-ping Wei, Ka Chung Lam, Hokto Kazama
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Age-dependent predictors of effective reinforcement motor learning across childhood

    Nayo M Hill, Haley M Tripp ... Amy J Bastian
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

    Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

    Malika Hale, Kennidy K Takehara ... Marion Pepper
    Revised
    Reviewed Preprint v2
    1. Ecology
    2. Microbiology and Infectious Disease

    Variation in thermal physiology can drive the temperature-dependence of microbial community richness

    Tom Clegg, Samraat Pawar
    A novel theory demonstrates how variation in the thermal responses of microbial populations can alter coexistance and thus explain patterns of richness across thermal gradients.
    1. Chromosomes and Gene Expression

    Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

    James Lee, Leman Simpson ... Lu Bai
    The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

    Shang Geng, Xing Lv ... Tianjun Xu
    5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
    1. Evolutionary Biology
    2. Neuroscience

    Neuro-evolutionary evidence for a universal fractal primate brain shape

    Yujiang Wang, Karoline Leiberg ... Bruno Mota
    Cortices from 11 primate species share the same archetypal fractal shape, indicating a universal mechanism for primate and mammalian cortical folding, and suggesting novel shape biomarkers for brains.
    1. Medicine
    2. Neuroscience

    Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

    Jörn Lötsch, Khayal Gasimli ... Marco Sisignano
    Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
    1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacteria

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
    Revised
    Reviewed Preprint v2
    1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi
    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
    1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali
    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
    1. Neuroscience

    Task-dependent coarticulation of movement sequences

    Hari Teja Kalidindi, Frederic Crevecoeur
    Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.
    1. Neuroscience

    Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    Fan Nils Yang, Dante Picchioni ... Jeff H Duyn
    Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
    1. Neuroscience

    High-frequency terahertz stimulation alleviates neuropathic pain by inhibiting the pyramidal neuron activity in the anterior cingulate cortex of mice

    Wenyu Peng, Pan Wang ... Tao Chen
    For the first time, high-frequency terahertz stimulation is shown to effectively alleviate chronic pain symptoms in mice by regulating neuronal activity in the cortex.
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho
    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
    1. Neuroscience

    History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

    Lisa Rother, Anna Stöckl, Keram Pfeiffer
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Cancer Biology

    Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes

    Jerko Rosko, Kelsey Cremin ... Orkun S Soyer
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

    Sihui Cai, Jie Zhou ... Jun Cui
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cortico-striatal action control inherent of opponent cognitive-motivational styles

    Cassandra Avila, Martin Sarter
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Expression of a single inhibitory Ly49 receptor is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Confirmation of HLA-II associations with TB susceptibility in admixed African samples

    Dayna Croock, Yolandi Swart ... Caitlin Uren
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

    Masaya Muramoto, Nozomi Hanawa ... Natsuki Shinoda
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease

    Edwin A Homan, Ankit Gilani ... James C Lo
    Revised
    Reviewed Preprint v2
    1. Medicine

    A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

    Mitsuru Sugimoto, Tadayuki Takagi ... Hiromasa Ohira
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman
    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
    1. Neuroscience

    Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia

    Merlin Monzel, Pitshaporn Leelaarporn ... Cornelia McCormick
    The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

    Kyusang Yoo, Young-Woo Jo ... Young-Yun Kong
    GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.
    1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Establishing comprehensive quaternary structural proteomes from genome sequence

    Edward Alexander Catoiu, Nathan Mih ... Bernhard Palsson
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

    Kelsey R Baron, Samantha Oviedo ... R Luke Wiseman
    Not revised
    Reviewed Preprint v1
    1. Ecology
    2. Evolutionary Biology

    Brochosomes as an antireflective camouflage coating for leafhoppers

    Wei Wu, Qianzhuo Mao ... Jian-Ping Chen
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Neuroscience

    Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    Naidi Sun, Yu-Yo Sun ... Song Hu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice

    Alessandro Piccin, Anne-Emilie Allain ... Angelo Contarino
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction

    Laura Fargeot, Camille Poesy ... Simon Blanchet
    Revised
    Reviewed Preprint v2
    1. Physics of Living Systems

    The exchange dynamics of biomolecular condensates

    Yaojun Zhang, Andrew GT Pyo ... Ned S Wingreen
    Exchange of components between biomolecular condensates and the surrounding dilute phase can be limited by dense-phase mixing, dilute-phase influx, or by the slow incorporation of molecules through the condensate interface.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

    Nathaniel Paul Meyer, Tania Singh ... Diane L Barber
    Clonal naïve human embryonic stem cells assemble an Arp2/3 complex-dependent contractile actin filament ring around colonies that promotes tensional forces favoring cell-cell adhesion and nuclear translocation of YAP to maintain ground-state pluripotency.
    1. Neuroscience

    A neural network model of differentiation and integration of competing memories

    Victoria JH Ritvo, Alex Nguyen ... Kenneth A Norman
    A computational neural network model leverages a simple unsupervised learning principle to account for recent findings on when memories move apart (differentiate) or together (integrate) in the brain.
    1. Cell Biology

    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

    Xiaojiao Hua, Chen Zhao ... Yan Zhou
    An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud
    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
    1. Neuroscience

    Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation

    Hendrik Heinbockel, Gregor Leicht ... Lars Schwabe
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Differential growth and transcriptomic profile of stem cell-derived midbrain astrocytes

    Zongze Li, Lucia Fernandez Cardo ... Meng Li
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

    Joonas A Autio, Ikko Kimura ... Takuya Hayashi
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Neuroscience

    Impact of liver specific survival motor neuron (SMN) depletion on peripheral and central nervous system tissue pathology

    Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression

    Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

    Houfang Zhang, Wenhan Guo ... Yunhui Peng
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

    Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos ... Javier Márquez-Ruiz
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

    Eleanor Martin, Rossana Girardello ... Alexander Ludwig
    Membrane tension controls the dynamic assembly and disassembly of caveolae and their association with the F-actin cortex in migrating cells.
    1. Neuroscience

    Distractor effects in decision making are related to the individual’s style of integrating choice attributes

    Jing Jun Wong, Alessandro Bongioanni ... Bolton KH Chau
    Computational modelling reveals variations in people’s preferences towards integrating choice attributes using an additive or multiplicative approach, which affected whether the presence of valuable distractors facilitate or impair decision making.
    1. Neuroscience

    When and why does motor preparation arise in recurrent neural network models of motor control?

    Marine Schimel, Ta-Chu Kao, Guillaume Hennequin
    A computational model shows that preparation arises as an optimal control strategy in input-driven recurrent neural networks performing a delayed-reaching task.
    1. Medicine

    Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    Megan M Sperry, Berenice Charrez ... Donald E Ingber
    Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue injury.
    1. Neuroscience

    Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking

    Victoria B Hosack, Fritzie I Arce-McShane
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Genetics and Genomics

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson
    Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
    1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V Chenchiah ... Helen Weavers
    Deep Learning Artificial Intelligence tools can be developed to accurately identify cell divisions during development and wound repair of epithelial tissue.
    1. Neuroscience

    The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding
    The subthalamic nucleus contains distinct subpopulations that can support multifaceted roles for making decisions based on uncertain evidence.
    1. Neuroscience

    Decreased Astrocytic CCL5 by MiR-324-5p Ameliorates Ischemic Stroke Injury via CCR5/ERK/CREB Pathway

    Jingxiu Li, Keyuan Gao ... Chenxi Sun
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Linalool’s Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica

    Tao Tang, Weiming Zhong ... Zhipeng Gao
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

    Claire Cooper, Daniel Parthier ... Dietmar Schmitz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

    Daniel Reznik, Piotr Majka ... Christian F Doeller
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi Dastjerdi ... Joachim HR Lübke
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

    Wenqin Fang, Xiaoyu Zai ... Wenhui Zheng
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Endogenous Precision of the Number Sense

    Arthur Prat-Carrabin, Michael Woodford
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Sharon Kaisari
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    NMDA receptor antagonist memantine selectively affects recurrent processing during perceptual inference

    Samuel Noorman, Timo Stein ... Simon van Gaal
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    MLCK/MLCP regulates mammalian axon regeneration via the redistribution of the growth cone F-actin

    Saijilafu, Wei-Hua Wang ... Yan-Xia Ma
    Revised
    Reviewed Preprint v2
    1. Cancer Biology

    PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram
    PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
    1. Medicine

    Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes

    Jiang Li, Yuefeng Yu ... Bin Wang
    Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.
    1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer
    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
    1. Neuroscience

    Sensitivity to vocal emotions emerges in newborns at 37 weeks gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang
    Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells
    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
    1. Cell Biology

    Exploring the role of macromolecular crowding and TNFR1 in cell volume control

    Parijat Biswas, Priyanka Roy ... Deepak Kumar Sinha
    Cells adapt to extracellular hypertonicities using regulatory volume increase (RVI), and TNFR1-mediated NFkB activation is indispensable for RVI, but the increased cytoplasmic macromolecular crowding can inhibit TNFR1 signaling and prevent RVI at severe hypertonicities.
    1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor
    Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe
    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
    1. Neuroscience

    Mechanism of barotaxis in marine zooplankton

    Luis Alberto Bezares Calderón, Réza Shahidi, Gáspár Jékely
    Ciliated zooplankton larvae sense pressure by ciliary photoreceptor cells, which increase the beating of locomotor cilia via a serotonergic motor circuit leading to rapid upward swimming during barotaxis.
    1. Cancer Biology

    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

    Anne Fajac, Iva Simeonova ... Franck Toledo
    The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
    1. Neuroscience

    Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

    Frederick Federer, Justin Balsor ... Alessandra Angelucci
    The gene-regulatory enhancers h56D and S5E2 restrict transgene expression to GABAergic and parvalbumin-positive interneurons, respectively, across marmoset cortical layers, thus representing a promising tool for circuit dissection in non-human primates.
    1. Immunology and Inflammation
    2. Neuroscience

    Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

    Alina Malita, Olga Kubrak ... Kim Rewitz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    Kevin C Lister, Calvin Wong ... Arkady Khoutorsky
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Ecology

    Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

    Chao Wen, Yuyi Lu ... Lars Chittka
    Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline

    Leif Benner, Savannah Muron ... Brian Oliver
    Many well-studied maternal developmental pathways that are required for embryonic development in Drosophila are regulated by the transcription factor OVO in the Drosophila female germline.
    1. Immunology and Inflammation

    The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

    Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin
    The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

    Sean A Ridout, Priyathama Vellanki, Ilya Nemenman
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

    Iuliia Ferling, Steffen Pfalzgraf ... Spencer A Freeman
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

    Affiong I Oqua, Kin Chao ... Alejandra Tomas
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

    GL Barlow, CM Schürch ... PL Bollyky
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    CausalXtract: a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

    Franck Simon, Maria Colomba Comes ... Hervé Isambert
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

    Yuan Chang, Savannah Lusk ... Russell S Ray
    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

    Hao Wang, Biying Zhu ... Zhaoliang Zhang
    Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
    1. Neuroscience

    Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    Moneeza A Agha, Sandeep Kishore, David L McLean
    Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.
    1. Neuroscience

    Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

    Stefan Passlick, Ghanim Ullah, Christian Henneberger
    Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
    1. Plant Biology

    OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

    Zongju Yang, Tianqi Bai ... Chen Chen
    OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.
    1. Neuroscience

    DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

    Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
    DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
    1. Neuroscience

    Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)

    Francesca S Wong, Alina B Thomas ... Nathan M Holmes
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Normative evidence weighting and accumulation in correlated environments

    Nathan Tardiff, Jiwon Kang, Joshua I Gold
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

    Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep

    Gergely F Turi, Sasa Teng ... Yueqing Peng
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

    Besma Brahmia, Yahaira Naaldijk ... Sabine Hilfiker
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Supralinear dendritic integration in murine dendrite-targeting interneurons

    Simonas Griesius, Amy Richardson, Dimitri M Kullmann
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

    Julia Belyaeva, Matthias Elgeti
    Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the CBC-ALYREF complex

    Bradley P Clarke, Alexia E Angelos ... Yi Ren
    Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
    1. Developmental Biology

    Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

    Saira Amir, Olatunbosun Arowolo ... Alexander Suvorov
    For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
    1. Structural Biology and Molecular Biophysics

    PPI-hotspotID for detecting protein–protein interaction hot spots from the free protein structure

    Yao Chi Chen, Karen Sargsyan ... Carmay Lim
    PPI-hotspotID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Single dopaminergic neuron DAN-c1 in Drosophila larval brain mediates aversive olfactory learning through D2-like receptors

    Cheng Qi, Cheng Qian ... Daewoo Lee
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Neuroscience

    Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

    Tomohiro Umeda, Ayumi Sakai ... Takami Tomiyama
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Robust variability of grid cell properties within individual grid modules enhances encoding of local space

    William T Redman, Santiago Acosta-Mendoza ... Michael J Goard
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
    1. Immunology and Inflammation

    Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

    Jiansen Lu, Jiahuan Zhang ... Xiao Yu
    Vangl2 induced by inflammation recruits ubiquitin ligase PDLIM2 and increases K63-linked ubiquitination on p65, which promotes the recognition of p65 by cargo receptor NDP52 and the autophagic degradation of p65.
    1. Developmental Biology

    TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    Jing Wang, Yingying Yin ... Zhaojian Liu
    Experiments on mice show that TMC7, a transmembrane channel-like protein, localizes to the cis-Golgi region in spermatids and that this is essential for acrosome biogenesis and male fertility.
    1. Cancer Biology

    Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

    Ruijing Tang, Luobin Guo ... Xiaolong Liu
    ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
    1. Neuroscience

    Language experience shapes predictive coding of rhythmic sound sequences

    Piermatteo Morucci, Sanjeev Nara ... Nicola Molinaro
    A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
    1. Immunology and Inflammation

    The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

    Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme
    The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
    1. Immunology and Inflammation

    Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

    Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker
    Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
    1. Medicine
    2. Computational and Systems Biology

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    Longxin Xie, Jessica Merjane ... Christopher J Donnelly
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A General Mechanism for the General Stress Response in Bacteria

    Rishika Baral, Kristin Ho ... Niels Bradshaw
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    AVN: A Deep Learning Approach for the Analysis of Birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

    Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

    Odessa R Yabut, Hector Gomez ... Samuel J Pleasure
    Revised
    Reviewed Preprint v2
    1. Evolutionary Biology

    Improved inference of population histories by integrating genomic and epigenomic data

    Thibaut Sellinger, Frank Johannes, Aurélien Tellier
    The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Neuroscience

    Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

    Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik
    Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
    1. Ecology

    Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

    Mathilde Delacoux, Fumihiro Kano
    Foveal vision in pigeons plays a crucial role in predator detection while the flock is collectively foraging and being vigilant.
    1. Cell Biology
    2. Neuroscience

    Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

    Luting Yang, Chunqing Hu ... Yaping Yan
    Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
    1. Cell Biology
    2. Immunology and Inflammation

    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

    Daniel M Williams, Andrew A Peden
    Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
    1. Medicine
    2. Immunology and Inflammation

    Preeclampsia-specific immune cell network in placenta revealed by Cytometry by time of flight and single-cell RNA-seq

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

    Shuo Chen, Jie Yin ... Peidong Han
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa V Goodrich
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Efficacy and mechanism of actions of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

    Rajae Talbi, Todd L Stincic ... Víctor M Navarro
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Cyclical MinD membrane affinity differences are not necessary for MinD gradient formation in Bacillus subtilis

    Laura C Bohorquez, Henrik Strahl ... Leendert W Hamoen
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Mechanistic Insights into MinD Regulation and Pattern Formation in Bacillus subtilis

    Helge Feddersen, Marc Bramkamp
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A unifying account of replay as context-driven memory reactivation

    Zhenglong Zhou, Michael J Kahana, Anna C Schapiro
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms

    Reham Abdelaziz, Adam P Tomczak ... Luis A Pardo
    The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
    1. Neuroscience

    Neuroelectrophysiology-compatible electrolytic lesioning

    Iliana E Bray, Stephen E Clarke ... Paul Nuyujukian
    Neuronal loss can be studied by passing electrical current through the same electrodes used for neuron measurement without disrupting recording ability.
    1. Cancer Biology

    Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

    Elazar Besser, Anat Gelfand ... David Meiri
    The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
    1. Cancer Biology

    Targeting ribosome biogenesis as a novel therapeutic approach to overcome EMT-related chemoresistance in breast cancer

    Yi Ban, Yue Zou ... Dingcheng Gao
    Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
    1. Developmental Biology
    2. Neuroscience

    Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

    Jialin Li, Feihong Yang ... Zhuangzhi Zhang
    The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.
    1. Developmental Biology
    2. Neuroscience

    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    Yuqi Cai, Zhirong Zhao ... Miao He
    Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
    1. Cell Biology

    Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease

    Kai-Ting Huang, Larry E Wagner ... David I Yule
    In a mouse model of Sjogren's disease, mitochondrial function and Ca2+ signaling are disrupted resulting in altered coupling between Ca2+ release and Ca2+ activated Cl- channels and salivary gland hypofunction.
    1. Computational and Systems Biology

    Identifying images in the biology literature that are problematic for people with a color-vision deficiency

    Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo
    Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
    1. Ecology

    Developmental stage shapes the realized energy landscape for a flight specialist

    Elham Nourani, Louise Faure ... Kamran Safi
    The realized energy landscape expands as animals improve their movement behaviors with age.
    1. Ecology

    Different coexistence patterns between apex carnivores and mesocarnivores based on temporal, spatial, and dietary niche partitioning analysis in Qilian Mountain National Park, China

    Wei Cong, Jia Li ... Yuguang Zhang
    Spatial segregation is identified as the primary mechanism facilitating the coexistence of apex and mesocarnivores in the Qilian Mountain National Park, China.
    1. Neuroscience

    Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity

    Fabian Schmidt, Sarah K Danböck ... Nathan Weisz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Should I stay or should I go? Spatio-temporal dynamics of bacterial biofilms in confined flows

    Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

    Erin M Ritchie, Siming Zhong ... Yishi Jin
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

    Lei Li, Guanghao Wu ... Yinchuan Li
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    Not revised
    Reviewed Preprint v1
    1. Plant Biology

    Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

    Yicong Wang, Masato Abe ... Nobutoshi Yamaguchi
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    A three filament mechanistic model of musculotendon force and impedance

    Matthew Millard, David W Franklin, Walter Herzog
    Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
    1. Neuroscience

    DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

    Ran-Der Hwang, YuNing Lu ... Jiou Wang
    A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.
    1. Neuroscience

    Speech-induced suppression and vocal feedback sensitivity in human cortex

    Muge Ozker, Leyao Yu ... Adeen Flinker
    During speech production, auditory regions that show speech-induced suppression are sensitive to changes in auditory feedback, suggesting that suppression may be a key mechanism underlying speech monitoring.
    1. Neuroscience

    Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

    Minsik Yun, Do-Hyoung Kim ... Young-Joon Kim
    Identification of central neural circuits and sensory pathways underlying social-sexual modulation of sperm ejection in female Drosophila unraveled cryptic mate choice, a mechanism of post-copulatory sexual selection.
    1. Neuroscience

    Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

    Guoqiang Wang, Ryan J Guasp ... Monica Driscoll
    Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

    Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte
    Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
    1. Neuroscience

    Individuals with anxiety and depression use atypical decision strategies in an uncertain world

    Zeming Fang, Meihua Zhao ... Ru-Yuan Zhang
    A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward environment.
    1. Stem Cells and Regenerative Medicine

    Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

    Zhixin Ma, Wenshu Wang ... Su Wang
    Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Genetics and Genomics

    Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
    Not revised
    Reviewed Preprint v1
    1. Epidemiology and Global Health

    From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

    Mengxun Luo, Jia Zhou ... Yelin Chen
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

    Guozhu Ning, Yu Lin ... Qiang Wang
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

    Meina He, Yongxin Tao ... Wenli Chen
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

    Lesia Semenova, Yingfan Wang ... Edward P Browne
    Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.
    1. Cell Biology

    Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

    Roberto Notario Manzano, Thibault Chaze ... Christel Brou
    Proteomic analysis of tunneling nanotubes (TNTs) identifies CD9 and CD81 as major positive regulators of TNT formation.
    1. Developmental Biology

    SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

    Rula Sha, Ruochen Guo ... Ying Feng
    Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
    1. Microbiology and Infectious Disease

    Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

    Srinivasan Vijay, Nguyen Le Hoai Bao ... Nguyen Thuy Thuong
    Isoniazid resistance in Mycobacterium tuberculosis is linked to higher rifampicin tolerance, necessitating evaluation and potential adjustment of treatment regimens to combat emerging multi-drug resistant variants.
    1. Immunology and Inflammation

    Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

    Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
    In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
    1. Evolutionary Biology

    Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima

    Hiroshi Arai, Susumu Katsuma ... Daisuke Kageyama
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction

    Xinyu Du, Haoxuan Xu ... Xiongjie Yu
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    PROTAC-induced Protein Functional Dynamics in Targeted Protein Degradation

    Kingsley Y Wu, Ta I Hung, Chia-en A Chang
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Neuroscience

    Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Cancer Biology

    RUNX2 Isoform II Protects Cancer Cells from Ferroptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Physics of Living Systems

    Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

    Bret A Unger, Chun Ying Wu ... Ke Xu
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan Shugarts, Aishwarya Sathya ... Antony M Jose
    Revised
    Reviewed Preprint v2
    1. Cell Biology
    2. Neuroscience

    CellSeg3D: self-supervised 3D cell segmentation for light-sheet microscopy

    Cyril Achard, Timokleia Kousi ... Mackenzie Weygandt Mathis
    Revised
    Reviewed Preprint v2
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Reversions mask the contribution of adaptive evolution in microbiomes

    Paul A Torrillo, Tami D Lieberman
    The timescale dependence of dN/dS in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

    Catherine A Weibel, Andrew L Wheeler ... Joanna Masel
    Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

    Jing Sun, Desmond Choy ... Shahram Kordasti
    ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
    1. Structural Biology and Molecular Biophysics

    Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE

    Xinyu Gu, Akashnathan Aranganathan, Pratyush Tiwary
    AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.
    1. Neuroscience

    Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

    Yoav Ger, Moni Shahar, Nitzan Shahar
    Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
    1. Neuroscience

    Novel cyclic homogeneous oscillation detection method for high accuracy and specific characterization of neural dynamics

    Hohyun Cho, Markus Adamek ... Peter Brunner
    Detecting neural oscillations in time and frequency domains enables the detailed study of spatiotemporal dynamics of oscillations throughout the brain and the investigation of biomarkers that index functional brain areas.
    1. Developmental Biology
    2. Genetics and Genomics

    Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

    Mitchell Bestry, Alexander N Larcombe ... David Martino
    Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
    1. Neuroscience

    The function of juvenile–adult transition axis in female sexual receptivity of Drosophila melanogaster

    Jing Li, Chao Ning ... Chuan Zhou
    Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.
    1. Neuroscience

    Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease

    Robert Englert, Balint Kincses ... Tamas Spisak
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Flexible neural representations of abstract structural knowledge in the human Entorhinal Cortex

    Shirley Mark, Phillipp Schwartenbeck ... Timothy E Behrens
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

    Thomas M Hallam, Emanuela Gardenal ... Amy V Jones
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids

    Nagatoshi Machii, Ryo Hatashima ... Masato Nikaido
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mixed representations of choice and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus

    Julianna Locantore, Yijun Liu ... Michael L Wallace
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo

    Su Young Han, Shel-Hwa Yeo ... Allan E Herbison
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers

    Agnieszka Glica, Katarzyna Wasilewska ... Katarzyna Jednoróg
    Revised
    Reviewed Preprint v2
    1. Immunology and Inflammation

    Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

    Fani Roumelioti, Christos Tzaferis ... George Kollias
    A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.
    1. Developmental Biology
    2. Neuroscience

    UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

    Pengfei Liu, Xinyi Liu, Bin Qi
    The cellular stress response pathway helps animals evaluate food quality and regulate feeding behavior to adapt in nutrient-deficient environments.
    1. Cancer Biology

    Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

    Sila Gerlevik, Nogayhan Seymen ... Mohammad M Karimi
    Multi-omics factor analysis reveals transposable element expression as a risk factor and inflammation as a protective factor in myelodysplastic syndromes (MDS).
    1. Neuroscience

    Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

    Katrin Franke, Chenchen Cai ... Andreas Savas Tolias
    Widespread color-opponency in mouse V1 enhances object decoding in the sky, highlighting the evolutionary importance of color processing in non-primate species.
    1. Neuroscience

    A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

    Yihe Weng, Johann Kruschwitz ... IMAGEN Consortium
    Differences in behavior and brain connectivity in young adolescents predicted future substance use.
    1. Cell Biology

    Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

    Ming Zhang, Guangyi Du ... Wei Chen
    Cardiovascular disease, the top cause of diabetic deaths, progresses via vascular endothelial dysfunction, with circHMGCS1 and miR4521 highlighted as potential markers for the development of this condition.
    1. Physics of Living Systems

    Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

    Alex James, Franca Buelow ... Ann Brower
    There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
    1. Neuroscience

    Analysis of fast calcium dynamics of honey bee olfactory coding

    Marco Paoli, Antoine Wystrach ... Martin Giurfa
    Fast calcium dynamics of honey bee olfactory projection neurons revealed an unprecedented heterogeneity of response profile dynamics and explained fundamental aspects of olfactory discrimination and associative learning.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

    Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

    Davinder Singh, Yajun Liu ... Jian-Qiu Wu
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

    Gabriele Baniulyte, Joseph T Wade
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Unraveling CRP/cAMP-Mediated Metabolic Regulation In Escherichia coli Persister Cells

    Han G Ngo, Sayed Golam Mohiuddin ... Mehmet A Orman
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Cancer Biology

    NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

    Connor M Hill, Alexandra Indeglia ... Alessandro Gardini
    Not revised
    Reviewed Preprint v1
    1. Epidemiology and Global Health

    Lifestyles and their relative contribution to biological aging across multiple organ systems: change analysis from the China Multi-Ethnic Cohort Study

    Yuan Zhang, Dan Tang ... Xing Zhao
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

    Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
    Revised
    Reviewed Preprint v2
    1. Computational and Systems Biology
    2. Neuroscience

    White matter structural bases for phase accuracy during tapping synchronization

    Pamela Garcia-Saldivar, Cynthia de León ... Hugo Merchant
    Comparison between tapping performance of humans during a synchronization task and new metrics that characterize the U-fiber system of white matter revealed large intersubject correlations between phase accuracy at specific tempos and the strength of connectivity in their audiomotor system.
    1. Biochemistry and Chemical Biology

    Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

    Aleksandar Bartolome, Julia C Heiby ... Alessandro Ori
    Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.
    1. Biochemistry and Chemical Biology

    Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

    Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Microbiology and Infectious Disease

    Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

    Yong Fan, Jiajun Ying ... Hanbin Cui
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm

    Sam Weeks, Dubravka Pezic ... Suzana Hadjur
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Stimulus representation in human frontal cortex supports flexible control in working memory

    Zhujun Shao, Mengya Zhang, Qing Yu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

    Yujie Fang, Zihan Guan ... Ke Peng
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Dynamics and Regulatory Roles of RNA m6A Methylation in Unbalanced Genomes

    Shuai Zhang, Xinyu Liu ... Lin Sun
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Yajun Zhai
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

    Ka Kiu Lee, Urszula Łapińska ... Stefano Pagliara
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

    Brennan J Wadsworth, Marina Leiwe ... Randall S Johnson
    The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.
    1. Genetics and Genomics

    Resetting of H3K4me2 during mammalian parental-to-zygote transition

    Chong Wang, Yong Shi ... Jiawei Xu
    Not revised
    Reviewed Preprint v1
    1. Stem Cells and Regenerative Medicine

    Sox9 marks limbal stem cells and is required for asymmetric cell fate switch in the corneal epithelium

    Gabriella Rice, Olivia Farrelly ... Panteleimon Rompolas
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

    Giorgia Greter, Claudia Moresi ... Markus Arnoldini
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Evolutionary Biology

    Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

    Chade Li, Ki Kei Chan ... Jerome HL Hui
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

    Jixing Li, Qixuan Wang ... Zhiwu Huang
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

    Patrick KA Kearns, Charles Dixon ... Nick Gilbert
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Genetics and Genomics

    Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

    Tao Cheng, Xiang Liu ... Peng-Fei Xu
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

    Ting Cai, Bei Zhang ... Zhihao Wu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    DeePosit: an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

    David Peles, Shai Netser ... Shlomo Wagner
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

    Zhen Wang, Jie Zhu ... Xiang Zhou
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    Tania Fuchsberger, Imogen Stockwell ... Ole Paulsen
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng
    Revised
    Reviewed Preprint v2
    1. Cell Biology

    Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
    Revised
    Reviewed Preprint v2
    1. Structural Biology and Molecular Biophysics

    The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

    Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev
    The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
    1. Computational and Systems Biology
    2. Developmental Biology

    Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo

    Juan Manuel Gomez, Hendrik Nolte ... Maria Leptin
    An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

    Po-Lin Chiu, Juan D Orjuela ... Thomas Walz
    Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
    1. Neuroscience

    Future movement plans interact in sequential arm movements

    Mehrdad Kashefi, Sasha Reschechtko ... J Andrew Pruszynski
    To ensure smooth sequential actions, reaches to at least two future targets are planned during the execution of the current reach and the planning processes of the future reaches interact.
    1. Evolutionary Biology

    The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles in Arabidopsis halleri and Arabidopsis lyrata

    Audrey Le Veve, Mathieu Genete ... Vincent Castric
    By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.
    1. Structural Biology and Molecular Biophysics

    Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

    Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar
    The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.

Magazine

  1. Two ants walking on a branch in the moonlight

    Episode 94: September 2024

    1. Medicine
    2. Neuroscience

    Pain Management: A promising alternative to opioids

    Jie Zhang, Jianguo Cheng
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Reprogramming: A perfect recipe for a corticospinal neuron

    Alfonso Aguilera, Marta Nieto
    1. Neuroscience

    Motor Networks: When preparation pays off

    Mark M Churchland
    1. Biochemistry and Chemical Biology

    Immunotherapy: The power lies in the glycans

    Luca Unione, Jesús Jiménez-Barbero
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Point of View: Teaching troubleshooting skills to graduate students

    Gina Partipilo, Yang Gao ... Benjamin K Keitz
    1. Cell Biology

    Kidney Fibrosis: Lock out SIRT4

    Kaiqiang Zhao, Zhongjun Zhou
    1. Medicine

    Point of View: Applied research won’t flourish without basic science

    Jon R Lorsch, Lawrence A Tabak, Monica M Bertagnolli
    1. Neuroscience

    Status Epilepticus: Stopping runaway seizures with a chill pill

    Gordon F Buchanan
    1. Neuroscience

    Sequential Movement: Reaching into the future

    Raeed H Chowdhury